Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis

The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart- reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were cros...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187616/
https://www.ncbi.nlm.nih.gov/pubmed/2985729
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collection PubMed
description The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart- reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis.
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spelling pubmed-21876162008-04-17 Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis J Exp Med Articles The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart- reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis. The Rockefeller University Press 1985-05-01 /pmc/articles/PMC2187616/ /pubmed/2985729 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis
title Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis
title_full Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis
title_fullStr Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis
title_full_unstemmed Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis
title_short Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis
title_sort heart-specific autoantibodies following murine coxsackievirus b3 myocarditis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187616/
https://www.ncbi.nlm.nih.gov/pubmed/2985729

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