Interleukin 2 upregulates expression of its receptor on a T cell clone

Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 anti...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187624/
https://www.ncbi.nlm.nih.gov/pubmed/3925066
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collection PubMed
description Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2- R molecules.
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spelling pubmed-21876242008-04-17 Interleukin 2 upregulates expression of its receptor on a T cell clone J Exp Med Articles Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2- R molecules. The Rockefeller University Press 1985-06-01 /pmc/articles/PMC2187624/ /pubmed/3925066 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Interleukin 2 upregulates expression of its receptor on a T cell clone
title Interleukin 2 upregulates expression of its receptor on a T cell clone
title_full Interleukin 2 upregulates expression of its receptor on a T cell clone
title_fullStr Interleukin 2 upregulates expression of its receptor on a T cell clone
title_full_unstemmed Interleukin 2 upregulates expression of its receptor on a T cell clone
title_short Interleukin 2 upregulates expression of its receptor on a T cell clone
title_sort interleukin 2 upregulates expression of its receptor on a t cell clone
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187624/
https://www.ncbi.nlm.nih.gov/pubmed/3925066

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