Suppression of in vivo tumor formation induced by simian virus 40- transformed cells in mice receiving antiidiotypic antibodies

This study characterizes four private idiotypes (Id) associated with monoclonal antibodies (mAb) to simian virus 40 (SV40) tumor antigen (T- Ag), and to a cellular protein, p53. Anti-Id recognized Id determinants associated with the antibody-combining site. BALB/c mice receiving a pool of anti-Id di...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187644/
https://www.ncbi.nlm.nih.gov/pubmed/2409201
_version_ 1782146222917681152
collection PubMed
description This study characterizes four private idiotypes (Id) associated with monoclonal antibodies (mAb) to simian virus 40 (SV40) tumor antigen (T- Ag), and to a cellular protein, p53. Anti-Id recognized Id determinants associated with the antibody-combining site. BALB/c mice receiving a pool of anti-Id directed against mAb recognizing distinct amino and carboxyl terminal epitopes of T-Ag before receiving a tumorigenic dose of SV40-transformed cells showed suppression of tumor formation. Serum obtained from these mice before tumor challenge contained anti-anti-Id that failed to bind T-Ag. These data support the potential role of regulatory idiotopes in tumor immunity.
format Text
id pubmed-2187644
institution National Center for Biotechnology Information
language English
publishDate 1985
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21876442008-04-17 Suppression of in vivo tumor formation induced by simian virus 40- transformed cells in mice receiving antiidiotypic antibodies J Exp Med Articles This study characterizes four private idiotypes (Id) associated with monoclonal antibodies (mAb) to simian virus 40 (SV40) tumor antigen (T- Ag), and to a cellular protein, p53. Anti-Id recognized Id determinants associated with the antibody-combining site. BALB/c mice receiving a pool of anti-Id directed against mAb recognizing distinct amino and carboxyl terminal epitopes of T-Ag before receiving a tumorigenic dose of SV40-transformed cells showed suppression of tumor formation. Serum obtained from these mice before tumor challenge contained anti-anti-Id that failed to bind T-Ag. These data support the potential role of regulatory idiotopes in tumor immunity. The Rockefeller University Press 1985-06-01 /pmc/articles/PMC2187644/ /pubmed/2409201 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Suppression of in vivo tumor formation induced by simian virus 40- transformed cells in mice receiving antiidiotypic antibodies
title Suppression of in vivo tumor formation induced by simian virus 40- transformed cells in mice receiving antiidiotypic antibodies
title_full Suppression of in vivo tumor formation induced by simian virus 40- transformed cells in mice receiving antiidiotypic antibodies
title_fullStr Suppression of in vivo tumor formation induced by simian virus 40- transformed cells in mice receiving antiidiotypic antibodies
title_full_unstemmed Suppression of in vivo tumor formation induced by simian virus 40- transformed cells in mice receiving antiidiotypic antibodies
title_short Suppression of in vivo tumor formation induced by simian virus 40- transformed cells in mice receiving antiidiotypic antibodies
title_sort suppression of in vivo tumor formation induced by simian virus 40- transformed cells in mice receiving antiidiotypic antibodies
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187644/
https://www.ncbi.nlm.nih.gov/pubmed/2409201

Ejemplares similares