Antigen-reactive T cell clones restricted by mixed isotype A beta d/E alpha d class II molecules

Mixed isotype A beta dE alpha d class II molecule-restricted antigen- reactive T cell clones were obtained from (BALB/c x B6E alpha d)F1 mice. These T cell clones responded to keyhole limpet hemocyanin in the presence of (BALB/c x B6E alpha d)F1 but not CBF1 APCs. Both anti-A beta d and anti-E alpha...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187720/
https://www.ncbi.nlm.nih.gov/pubmed/2303787
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collection PubMed
description Mixed isotype A beta dE alpha d class II molecule-restricted antigen- reactive T cell clones were obtained from (BALB/c x B6E alpha d)F1 mice. These T cell clones responded to keyhole limpet hemocyanin in the presence of (BALB/c x B6E alpha d)F1 but not CBF1 APCs. Both anti-A beta d and anti-E alpha mAbs blocked the proliferative responses of these clones. The frequency of such mixed isotype A beta E alpha- restricted T cell clones in (BALB/c x B6E alpha d)F1 mice was estimated to be approximately 10% from our limiting dilution cloning. The existence of such mixed isotype class II molecule-restricted T cells would have important implications for the expansion of the T cell repertoire as well as the induction of autoimmunity.
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spelling pubmed-21877202008-04-17 Antigen-reactive T cell clones restricted by mixed isotype A beta d/E alpha d class II molecules J Exp Med Articles Mixed isotype A beta dE alpha d class II molecule-restricted antigen- reactive T cell clones were obtained from (BALB/c x B6E alpha d)F1 mice. These T cell clones responded to keyhole limpet hemocyanin in the presence of (BALB/c x B6E alpha d)F1 but not CBF1 APCs. Both anti-A beta d and anti-E alpha mAbs blocked the proliferative responses of these clones. The frequency of such mixed isotype A beta E alpha- restricted T cell clones in (BALB/c x B6E alpha d)F1 mice was estimated to be approximately 10% from our limiting dilution cloning. The existence of such mixed isotype class II molecule-restricted T cells would have important implications for the expansion of the T cell repertoire as well as the induction of autoimmunity. The Rockefeller University Press 1990-02-01 /pmc/articles/PMC2187720/ /pubmed/2303787 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Antigen-reactive T cell clones restricted by mixed isotype A beta d/E alpha d class II molecules
title Antigen-reactive T cell clones restricted by mixed isotype A beta d/E alpha d class II molecules
title_full Antigen-reactive T cell clones restricted by mixed isotype A beta d/E alpha d class II molecules
title_fullStr Antigen-reactive T cell clones restricted by mixed isotype A beta d/E alpha d class II molecules
title_full_unstemmed Antigen-reactive T cell clones restricted by mixed isotype A beta d/E alpha d class II molecules
title_short Antigen-reactive T cell clones restricted by mixed isotype A beta d/E alpha d class II molecules
title_sort antigen-reactive t cell clones restricted by mixed isotype a beta d/e alpha d class ii molecules
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187720/
https://www.ncbi.nlm.nih.gov/pubmed/2303787

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