N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response

The B6 anti-bm6 allospecific CTL response is strictly dependent on CD4+ cells when using LPS blasts as stimulator cells. Altering the N-linked carbohydrates on stimulator cells by use of the N-linked trimming glycosidase inhibitors 1-deoxymannojirimycin and swainsonine, or by treatment with bacteria...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187723/
https://www.ncbi.nlm.nih.gov/pubmed/2303788
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collection PubMed
description The B6 anti-bm6 allospecific CTL response is strictly dependent on CD4+ cells when using LPS blasts as stimulator cells. Altering the N-linked carbohydrates on stimulator cells by use of the N-linked trimming glycosidase inhibitors 1-deoxymannojirimycin and swainsonine, or by treatment with bacterial neuraminidase, results in a restoration of the B6 anti-bm6 response in the absence of CD4+ cells. The extent of restoration is inversely correlated with the number of sialic acids present on N-linked glycans of stimulator cells.
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spelling pubmed-21877232008-04-17 N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response J Exp Med Articles The B6 anti-bm6 allospecific CTL response is strictly dependent on CD4+ cells when using LPS blasts as stimulator cells. Altering the N-linked carbohydrates on stimulator cells by use of the N-linked trimming glycosidase inhibitors 1-deoxymannojirimycin and swainsonine, or by treatment with bacterial neuraminidase, results in a restoration of the B6 anti-bm6 response in the absence of CD4+ cells. The extent of restoration is inversely correlated with the number of sialic acids present on N-linked glycans of stimulator cells. The Rockefeller University Press 1990-02-01 /pmc/articles/PMC2187723/ /pubmed/2303788 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response
title N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response
title_full N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response
title_fullStr N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response
title_full_unstemmed N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response
title_short N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response
title_sort n-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic t cell response
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187723/
https://www.ncbi.nlm.nih.gov/pubmed/2303788

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