Antigen valence determines the binding of nominal antigen to cytolytic T cell clones

We have shown that cytotoxic T cell clones specific for the nominal antigen FL will bind high molecular weight (600,000 to 2,000,000) polyacrylamide and Ficoll polymers conjugated with 200-600 FL groups per molecule. Low molecular weight polymers (40,000) with the same epitope density did not give s...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187759/
https://www.ncbi.nlm.nih.gov/pubmed/2410534
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collection PubMed
description We have shown that cytotoxic T cell clones specific for the nominal antigen FL will bind high molecular weight (600,000 to 2,000,000) polyacrylamide and Ficoll polymers conjugated with 200-600 FL groups per molecule. Low molecular weight polymers (40,000) with the same epitope density did not give stable binding. A high molecular weight polymer with a lower epitope density also failed to bind. Taken together, these results suggest that a substantial degree of multivalence is a necessary factor in the stable binding of nominal antigen to T cell clones.
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spelling pubmed-21877592008-04-17 Antigen valence determines the binding of nominal antigen to cytolytic T cell clones J Exp Med Articles We have shown that cytotoxic T cell clones specific for the nominal antigen FL will bind high molecular weight (600,000 to 2,000,000) polyacrylamide and Ficoll polymers conjugated with 200-600 FL groups per molecule. Low molecular weight polymers (40,000) with the same epitope density did not give stable binding. A high molecular weight polymer with a lower epitope density also failed to bind. Taken together, these results suggest that a substantial degree of multivalence is a necessary factor in the stable binding of nominal antigen to T cell clones. The Rockefeller University Press 1985-08-01 /pmc/articles/PMC2187759/ /pubmed/2410534 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Antigen valence determines the binding of nominal antigen to cytolytic T cell clones
title Antigen valence determines the binding of nominal antigen to cytolytic T cell clones
title_full Antigen valence determines the binding of nominal antigen to cytolytic T cell clones
title_fullStr Antigen valence determines the binding of nominal antigen to cytolytic T cell clones
title_full_unstemmed Antigen valence determines the binding of nominal antigen to cytolytic T cell clones
title_short Antigen valence determines the binding of nominal antigen to cytolytic T cell clones
title_sort antigen valence determines the binding of nominal antigen to cytolytic t cell clones
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187759/
https://www.ncbi.nlm.nih.gov/pubmed/2410534

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