Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma

Clonality in the non-neoplastic T cell population was investigated in 21 patients with B cell chronic leukemic (B-CLL) or multiple myeloma (MM) by probing for TCR beta chain gene rearrangements using Southern blot analysis. In three patients with a benign form of B-CLL (stage 0), and in one patient...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187776/
https://www.ncbi.nlm.nih.gov/pubmed/2137853
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collection PubMed
description Clonality in the non-neoplastic T cell population was investigated in 21 patients with B cell chronic leukemic (B-CLL) or multiple myeloma (MM) by probing for TCR beta chain gene rearrangements using Southern blot analysis. In three patients with a benign form of B-CLL (stage 0), and in one patient with smoldering MM, evidence was found for predominant T cell clones. As cellular immunity against the malignant cells may be important in leukemia, the results are discussed in view of the potential role of T cell immunity in B-CLL and MM.
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spelling pubmed-21877762008-04-17 Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma J Exp Med Articles Clonality in the non-neoplastic T cell population was investigated in 21 patients with B cell chronic leukemic (B-CLL) or multiple myeloma (MM) by probing for TCR beta chain gene rearrangements using Southern blot analysis. In three patients with a benign form of B-CLL (stage 0), and in one patient with smoldering MM, evidence was found for predominant T cell clones. As cellular immunity against the malignant cells may be important in leukemia, the results are discussed in view of the potential role of T cell immunity in B-CLL and MM. The Rockefeller University Press 1990-03-01 /pmc/articles/PMC2187776/ /pubmed/2137853 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma
title Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma
title_full Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma
title_fullStr Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma
title_full_unstemmed Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma
title_short Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma
title_sort presence of clonal t cell populations in chronic b lymphocytic leukemia and smoldering myeloma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187776/
https://www.ncbi.nlm.nih.gov/pubmed/2137853

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