Soluble CD23 (Fc epsilon RII) and interleukin 1 synergistically induce early human thymocyte maturation

The ability of human thymus-derived CD7+CD2-CD3- cells to acquire mature T cell antigens was assessed. Purified CD7+ thymocytes were incubated with rIL-1, rIL-2, and/or recombinant soluble CD23 (rsCD23). Short-term incubation of these cells with only rsCD23 + rIL-1 induced mature T cell antigen expr...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187780/
https://www.ncbi.nlm.nih.gov/pubmed/2137858
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collection PubMed
description The ability of human thymus-derived CD7+CD2-CD3- cells to acquire mature T cell antigens was assessed. Purified CD7+ thymocytes were incubated with rIL-1, rIL-2, and/or recombinant soluble CD23 (rsCD23). Short-term incubation of these cells with only rsCD23 + rIL-1 induced mature T cell antigen expression on at least half of the cells. The induction of CD2 was functionally significant, as these cells became able to respond to CD2 triggering and could proliferate in response to IL-2. Possible sources of CD23 in the thymus are under investigation.
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spelling pubmed-21877802008-04-17 Soluble CD23 (Fc epsilon RII) and interleukin 1 synergistically induce early human thymocyte maturation J Exp Med Articles The ability of human thymus-derived CD7+CD2-CD3- cells to acquire mature T cell antigens was assessed. Purified CD7+ thymocytes were incubated with rIL-1, rIL-2, and/or recombinant soluble CD23 (rsCD23). Short-term incubation of these cells with only rsCD23 + rIL-1 induced mature T cell antigen expression on at least half of the cells. The induction of CD2 was functionally significant, as these cells became able to respond to CD2 triggering and could proliferate in response to IL-2. Possible sources of CD23 in the thymus are under investigation. The Rockefeller University Press 1990-03-01 /pmc/articles/PMC2187780/ /pubmed/2137858 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Soluble CD23 (Fc epsilon RII) and interleukin 1 synergistically induce early human thymocyte maturation
title Soluble CD23 (Fc epsilon RII) and interleukin 1 synergistically induce early human thymocyte maturation
title_full Soluble CD23 (Fc epsilon RII) and interleukin 1 synergistically induce early human thymocyte maturation
title_fullStr Soluble CD23 (Fc epsilon RII) and interleukin 1 synergistically induce early human thymocyte maturation
title_full_unstemmed Soluble CD23 (Fc epsilon RII) and interleukin 1 synergistically induce early human thymocyte maturation
title_short Soluble CD23 (Fc epsilon RII) and interleukin 1 synergistically induce early human thymocyte maturation
title_sort soluble cd23 (fc epsilon rii) and interleukin 1 synergistically induce early human thymocyte maturation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187780/
https://www.ncbi.nlm.nih.gov/pubmed/2137858

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