DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma

To study the potential involvement of IL-6 in the development of plasmacytomas, a number of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement due to the insertion of an intracisternal A particle retrotransposon 18 bp 5' of the transcriptional start site was...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187786/
https://www.ncbi.nlm.nih.gov/pubmed/2106569
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description To study the potential involvement of IL-6 in the development of plasmacytomas, a number of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement due to the insertion of an intracisternal A particle retrotransposon 18 bp 5' of the transcriptional start site was detected in the cell line MPC11. The IL- 6 gene is constitutively expressed in MPC11, suggesting the involvement of IL-6 in the development of certain myeloma/plasmacytomas according to the "autocrine growth hypothesis".
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spelling pubmed-21877862008-04-17 DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma J Exp Med Articles To study the potential involvement of IL-6 in the development of plasmacytomas, a number of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement due to the insertion of an intracisternal A particle retrotransposon 18 bp 5' of the transcriptional start site was detected in the cell line MPC11. The IL- 6 gene is constitutively expressed in MPC11, suggesting the involvement of IL-6 in the development of certain myeloma/plasmacytomas according to the "autocrine growth hypothesis". The Rockefeller University Press 1990-03-01 /pmc/articles/PMC2187786/ /pubmed/2106569 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma
title DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma
title_full DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma
title_fullStr DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma
title_full_unstemmed DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma
title_short DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma
title_sort dna rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187786/
https://www.ncbi.nlm.nih.gov/pubmed/2106569

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