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Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75 [published erratum appears in J Exp Med 1990 Jun 1;171(6):2183]

We have recently established a mAb named TU11 mAb specific for the p75 subunit of human IL-2 receptor (IL-2R). The present study using TU11 mAb demonstrates the IL-2-induced phosphorylation of IL-2Rp75 on tyrosine residues in IL-2-dependent T cells. The tyrosine phosphorylation is mediated by the hi...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187791/
https://www.ncbi.nlm.nih.gov/pubmed/2106566
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collection PubMed
description We have recently established a mAb named TU11 mAb specific for the p75 subunit of human IL-2 receptor (IL-2R). The present study using TU11 mAb demonstrates the IL-2-induced phosphorylation of IL-2Rp75 on tyrosine residues in IL-2-dependent T cells. The tyrosine phosphorylation is mediated by the high affinity IL-2R, correlates with the IL-2-induced cell growth, and rapidly increases during the first 5 min of IL-2 stimulation. Phosphorylation of serine and threonine residues of IL-2Rp75 is also detected, but its IL-2 dependency is not significant during at least the first 5 min. These results suggest some roles of a tyrosine kinase associated with IL-2Rp75 in the IL-2-induced signal-transducing pathway.
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spelling pubmed-21877912008-04-17 Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75 [published erratum appears in J Exp Med 1990 Jun 1;171(6):2183] J Exp Med Articles We have recently established a mAb named TU11 mAb specific for the p75 subunit of human IL-2 receptor (IL-2R). The present study using TU11 mAb demonstrates the IL-2-induced phosphorylation of IL-2Rp75 on tyrosine residues in IL-2-dependent T cells. The tyrosine phosphorylation is mediated by the high affinity IL-2R, correlates with the IL-2-induced cell growth, and rapidly increases during the first 5 min of IL-2 stimulation. Phosphorylation of serine and threonine residues of IL-2Rp75 is also detected, but its IL-2 dependency is not significant during at least the first 5 min. These results suggest some roles of a tyrosine kinase associated with IL-2Rp75 in the IL-2-induced signal-transducing pathway. The Rockefeller University Press 1990-03-01 /pmc/articles/PMC2187791/ /pubmed/2106566 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75 [published erratum appears in J Exp Med 1990 Jun 1;171(6):2183]
title Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75 [published erratum appears in J Exp Med 1990 Jun 1;171(6):2183]
title_full Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75 [published erratum appears in J Exp Med 1990 Jun 1;171(6):2183]
title_fullStr Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75 [published erratum appears in J Exp Med 1990 Jun 1;171(6):2183]
title_full_unstemmed Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75 [published erratum appears in J Exp Med 1990 Jun 1;171(6):2183]
title_short Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75 [published erratum appears in J Exp Med 1990 Jun 1;171(6):2183]
title_sort interleukin 2 (il-2)-induced tyrosine phosphorylation of il-2 receptor p75 [published erratum appears in j exp med 1990 jun 1;171(6):2183]
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187791/
https://www.ncbi.nlm.nih.gov/pubmed/2106566