Growth factor-mediated tumor cell proliferation in hairy cell leukemia

Leukemic B cells from seven patients with hairy cell leukemia (HCL), six of which contained the Tac antigen, were assayed in vitro for growth factor-mediated cell proliferation. The HCL cells showed typical phenotypic profiles by monoclonal antibody analysis. The tumor cells, which do not grow spont...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187808/
https://www.ncbi.nlm.nih.gov/pubmed/2993470
_version_ 1782146260724088832
collection PubMed
description Leukemic B cells from seven patients with hairy cell leukemia (HCL), six of which contained the Tac antigen, were assayed in vitro for growth factor-mediated cell proliferation. The HCL cells showed typical phenotypic profiles by monoclonal antibody analysis. The tumor cells, which do not grow spontaneously in vitro, were found to proliferate in all but one case in response to partially purified B cell growth factor (BCGF) without anti-mu or Sac activation. Recombinant interleukin 2 however produced only a marginal response and could not support leukemic cell growth in vitro. BCGF, however, did stimulate in vitro cell growth and supported the establishment of continuous (greater than 60 d in vitro) in four of the seven HCL cases.
format Text
id pubmed-2187808
institution National Center for Biotechnology Information
language English
publishDate 1985
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21878082008-04-17 Growth factor-mediated tumor cell proliferation in hairy cell leukemia J Exp Med Articles Leukemic B cells from seven patients with hairy cell leukemia (HCL), six of which contained the Tac antigen, were assayed in vitro for growth factor-mediated cell proliferation. The HCL cells showed typical phenotypic profiles by monoclonal antibody analysis. The tumor cells, which do not grow spontaneously in vitro, were found to proliferate in all but one case in response to partially purified B cell growth factor (BCGF) without anti-mu or Sac activation. Recombinant interleukin 2 however produced only a marginal response and could not support leukemic cell growth in vitro. BCGF, however, did stimulate in vitro cell growth and supported the establishment of continuous (greater than 60 d in vitro) in four of the seven HCL cases. The Rockefeller University Press 1985-09-01 /pmc/articles/PMC2187808/ /pubmed/2993470 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Growth factor-mediated tumor cell proliferation in hairy cell leukemia
title Growth factor-mediated tumor cell proliferation in hairy cell leukemia
title_full Growth factor-mediated tumor cell proliferation in hairy cell leukemia
title_fullStr Growth factor-mediated tumor cell proliferation in hairy cell leukemia
title_full_unstemmed Growth factor-mediated tumor cell proliferation in hairy cell leukemia
title_short Growth factor-mediated tumor cell proliferation in hairy cell leukemia
title_sort growth factor-mediated tumor cell proliferation in hairy cell leukemia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187808/
https://www.ncbi.nlm.nih.gov/pubmed/2993470

Ejemplares similares