Helper T cells reacting to idiotype on IgG but not IgM

Immunization with an IgG1 but not an IgM monoclonal anti-NP (4-hydroxy- 3-nitrophenyl acetyl) antibody induced idiotype-recognizing T helper cells, although these two antibodies carry the same variable regions. The T cells appear to react to an idiotype on the IgG1 but not the IgM antibody. They sel...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187853/
https://www.ncbi.nlm.nih.gov/pubmed/2931497
Descripción
Sumario:Immunization with an IgG1 but not an IgM monoclonal anti-NP (4-hydroxy- 3-nitrophenyl acetyl) antibody induced idiotype-recognizing T helper cells, although these two antibodies carry the same variable regions. The T cells appear to react to an idiotype on the IgG1 but not the IgM antibody. They selectively enhance the expression of that idiotype in the IgG1 fraction of an in vitro anti-NP response.

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