Expression and role of p75 interleukin 2 receptor on human monocytes

We investigated the expression of IL-2R subunits in human monocytes using the TU27 mAb, which recognizes the p75 chain, and anti-Tac mAb, which recognizes the p55 moiety of the IL-2R. We found that p75 but not p55 is constitutively expressed in more than 90% of fresh human monocytes. Antibody to p75...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187901/
https://www.ncbi.nlm.nih.gov/pubmed/2110244
_version_ 1782146282420174848
collection PubMed
description We investigated the expression of IL-2R subunits in human monocytes using the TU27 mAb, which recognizes the p75 chain, and anti-Tac mAb, which recognizes the p55 moiety of the IL-2R. We found that p75 but not p55 is constitutively expressed in more than 90% of fresh human monocytes. Antibody to p75, but not to p55, inhibited the activation of monocytes to a cytotoxic stage induced by IL-2 but did not block IFN- gamma-induced cytotoxicity. Our data demonstrate that the p75 chain is expressed on human monocytes and is involved in the activation of monocytes by IL-2.
format Text
id pubmed-2187901
institution National Center for Biotechnology Information
language English
publishDate 1990
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21879012008-04-17 Expression and role of p75 interleukin 2 receptor on human monocytes J Exp Med Articles We investigated the expression of IL-2R subunits in human monocytes using the TU27 mAb, which recognizes the p75 chain, and anti-Tac mAb, which recognizes the p55 moiety of the IL-2R. We found that p75 but not p55 is constitutively expressed in more than 90% of fresh human monocytes. Antibody to p75, but not to p55, inhibited the activation of monocytes to a cytotoxic stage induced by IL-2 but did not block IFN- gamma-induced cytotoxicity. Our data demonstrate that the p75 chain is expressed on human monocytes and is involved in the activation of monocytes by IL-2. The Rockefeller University Press 1990-05-01 /pmc/articles/PMC2187901/ /pubmed/2110244 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Expression and role of p75 interleukin 2 receptor on human monocytes
title Expression and role of p75 interleukin 2 receptor on human monocytes
title_full Expression and role of p75 interleukin 2 receptor on human monocytes
title_fullStr Expression and role of p75 interleukin 2 receptor on human monocytes
title_full_unstemmed Expression and role of p75 interleukin 2 receptor on human monocytes
title_short Expression and role of p75 interleukin 2 receptor on human monocytes
title_sort expression and role of p75 interleukin 2 receptor on human monocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187901/
https://www.ncbi.nlm.nih.gov/pubmed/2110244

Ejemplares similares