Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide

Induction in vivo of antiviral cytotoxic T cell response was achieved in a MHC class I-dependent fashion by immunizing mice three times with a free unmodified 15-mer peptide derived from the nucleoprotein of lymphocytic choriomeningitis virus in IFA. The effector T cells are CD8+, restricted to the...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187909/
https://www.ncbi.nlm.nih.gov/pubmed/1692084
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description Induction in vivo of antiviral cytotoxic T cell response was achieved in a MHC class I-dependent fashion by immunizing mice three times with a free unmodified 15-mer peptide derived from the nucleoprotein of lymphocytic choriomeningitis virus in IFA. The effector T cells are CD8+, restricted to the class I Ld allele of the analyzed mouse strain, and are specific both at the level of secondary restimulation in vitro and at the effector T cell level. These results suggest that cocktails of viral peptides may be used as antiviral T cell vaccines.
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spelling pubmed-21879092008-04-17 Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide J Exp Med Articles Induction in vivo of antiviral cytotoxic T cell response was achieved in a MHC class I-dependent fashion by immunizing mice three times with a free unmodified 15-mer peptide derived from the nucleoprotein of lymphocytic choriomeningitis virus in IFA. The effector T cells are CD8+, restricted to the class I Ld allele of the analyzed mouse strain, and are specific both at the level of secondary restimulation in vitro and at the effector T cell level. These results suggest that cocktails of viral peptides may be used as antiviral T cell vaccines. The Rockefeller University Press 1990-05-01 /pmc/articles/PMC2187909/ /pubmed/1692084 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide
title Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide
title_full Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide
title_fullStr Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide
title_full_unstemmed Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide
title_short Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide
title_sort antiviral cytotoxic t cell response induced by in vivo priming with a free synthetic peptide
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187909/
https://www.ncbi.nlm.nih.gov/pubmed/1692084

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