An arthritogenic lymphokine in the rat

A type II collagen-specific arthritogenic lymphokine has been identified in the rat. Arthritogenic factor (AF) is a 65 kD protein generated in vitro by T cells from rats with collagen arthritis, and it induces an erosive, proliferative synovitis when injected into the knee joint of syngeneic naive r...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187934/
https://www.ncbi.nlm.nih.gov/pubmed/3877139
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collection PubMed
description A type II collagen-specific arthritogenic lymphokine has been identified in the rat. Arthritogenic factor (AF) is a 65 kD protein generated in vitro by T cells from rats with collagen arthritis, and it induces an erosive, proliferative synovitis when injected into the knee joint of syngeneic naive recipients. Complement does not appear to be required. These data identify a potential T cell-mediated effector mechanism in this model, and suggest that AF may function in other inflammatory synovial diseases.
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spelling pubmed-21879342008-04-17 An arthritogenic lymphokine in the rat J Exp Med Articles A type II collagen-specific arthritogenic lymphokine has been identified in the rat. Arthritogenic factor (AF) is a 65 kD protein generated in vitro by T cells from rats with collagen arthritis, and it induces an erosive, proliferative synovitis when injected into the knee joint of syngeneic naive recipients. Complement does not appear to be required. These data identify a potential T cell-mediated effector mechanism in this model, and suggest that AF may function in other inflammatory synovial diseases. The Rockefeller University Press 1985-11-01 /pmc/articles/PMC2187934/ /pubmed/3877139 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
An arthritogenic lymphokine in the rat
title An arthritogenic lymphokine in the rat
title_full An arthritogenic lymphokine in the rat
title_fullStr An arthritogenic lymphokine in the rat
title_full_unstemmed An arthritogenic lymphokine in the rat
title_short An arthritogenic lymphokine in the rat
title_sort arthritogenic lymphokine in the rat
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187934/
https://www.ncbi.nlm.nih.gov/pubmed/3877139

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