Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1

By three criteria, we have demonstrated that B cell stimulatory factor (BSF-1) and B cell differentiation factor (BCDF-gamma) are the same lymphokine. Highly purified preparations of high performance liquid chromatography-purified or affinity-purified BSF-1 had BCDF-gamma activity but not BCDF-mu ac...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187936/
https://www.ncbi.nlm.nih.gov/pubmed/3932582
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collection PubMed
description By three criteria, we have demonstrated that B cell stimulatory factor (BSF-1) and B cell differentiation factor (BCDF-gamma) are the same lymphokine. Highly purified preparations of high performance liquid chromatography-purified or affinity-purified BSF-1 had BCDF-gamma activity but not BCDF-mu activity. A monoclonal anti-BSF-1 antibody coupled to Sepharose depleted both BSF-1 and BCDF-gamma activity but not BCDF-mu activity from two different T cell supernatants. Soluble monoclonal anti-BSF-1 blocked the BSF-1 and BCDF-gamma but not the BCDF- mu responses. These results suggest that BSF-1 acts on both resting and activated B cells to induce different effects.
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spelling pubmed-21879362008-04-17 Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1 J Exp Med Articles By three criteria, we have demonstrated that B cell stimulatory factor (BSF-1) and B cell differentiation factor (BCDF-gamma) are the same lymphokine. Highly purified preparations of high performance liquid chromatography-purified or affinity-purified BSF-1 had BCDF-gamma activity but not BCDF-mu activity. A monoclonal anti-BSF-1 antibody coupled to Sepharose depleted both BSF-1 and BCDF-gamma activity but not BCDF-mu activity from two different T cell supernatants. Soluble monoclonal anti-BSF-1 blocked the BSF-1 and BCDF-gamma but not the BCDF- mu responses. These results suggest that BSF-1 acts on both resting and activated B cells to induce different effects. The Rockefeller University Press 1985-11-01 /pmc/articles/PMC2187936/ /pubmed/3932582 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1
title Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1
title_full Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1
title_fullStr Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1
title_full_unstemmed Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1
title_short Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1
title_sort serological, biochemical, and functional identity of b cell-stimulatory factor 1 and b cell differentiation factor for igg1
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187936/
https://www.ncbi.nlm.nih.gov/pubmed/3932582

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