An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice

Autoantibodies against the 70-kD U1 RNP nucleoprotein autoantigen and DNA were elicited in normal BALB/c mice with a purified Ig light chain. This light chain, derived from a lupus-prone MRL-lpr/lpr mouse, has two distinctive properties: it contains an idiotypic marker recognized by a monoclonal MRL...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187956/
https://www.ncbi.nlm.nih.gov/pubmed/1693654
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collection PubMed
description Autoantibodies against the 70-kD U1 RNP nucleoprotein autoantigen and DNA were elicited in normal BALB/c mice with a purified Ig light chain. This light chain, derived from a lupus-prone MRL-lpr/lpr mouse, has two distinctive properties: it contains an idiotypic marker recognized by a monoclonal MRL-lpr/lpr anti-snRNP autoantibody, and the amino acid sequence of its third hypervariable region (CDR3) is homologous to a sequence in an antigenic region of the 70-kD U1 RNP polypeptide. The results demonstrate that an Ig idiotype that mimics an autoantigen can induce autoimmunization.
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spelling pubmed-21879562008-04-17 An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice J Exp Med Articles Autoantibodies against the 70-kD U1 RNP nucleoprotein autoantigen and DNA were elicited in normal BALB/c mice with a purified Ig light chain. This light chain, derived from a lupus-prone MRL-lpr/lpr mouse, has two distinctive properties: it contains an idiotypic marker recognized by a monoclonal MRL-lpr/lpr anti-snRNP autoantibody, and the amino acid sequence of its third hypervariable region (CDR3) is homologous to a sequence in an antigenic region of the 70-kD U1 RNP polypeptide. The results demonstrate that an Ig idiotype that mimics an autoantigen can induce autoimmunization. The Rockefeller University Press 1990-06-01 /pmc/articles/PMC2187956/ /pubmed/1693654 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice
title An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice
title_full An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice
title_fullStr An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice
title_full_unstemmed An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice
title_short An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice
title_sort immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187956/
https://www.ncbi.nlm.nih.gov/pubmed/1693654

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