Evidence for a shared HLA-A intralocus determinant defined by monoclonal antibody 131

We describe here a monoclonal antibody, 131, which appears to recognize a determinant shared by HLA-A locus-encoded gene products. Isoelectric focusing analysis demonstrates that 131 reacts with the products of at least seven different HLA-A alleles but none of the five HLA-B allelic products tested...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187978/
https://www.ncbi.nlm.nih.gov/pubmed/2415655
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collection PubMed
description We describe here a monoclonal antibody, 131, which appears to recognize a determinant shared by HLA-A locus-encoded gene products. Isoelectric focusing analysis demonstrates that 131 reacts with the products of at least seven different HLA-A alleles but none of the five HLA-B allelic products tested. Together with evidence provided by other studies, this finding indicates the existence of A-unique and B-unique determinants, which may have different biological functions. Monoclonal antibody probes, such as the one described here, specific for shared intralocus determinants, may be valuable for assessing these possible functional differences.
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spelling pubmed-21879782008-04-17 Evidence for a shared HLA-A intralocus determinant defined by monoclonal antibody 131 J Exp Med Articles We describe here a monoclonal antibody, 131, which appears to recognize a determinant shared by HLA-A locus-encoded gene products. Isoelectric focusing analysis demonstrates that 131 reacts with the products of at least seven different HLA-A alleles but none of the five HLA-B allelic products tested. Together with evidence provided by other studies, this finding indicates the existence of A-unique and B-unique determinants, which may have different biological functions. Monoclonal antibody probes, such as the one described here, specific for shared intralocus determinants, may be valuable for assessing these possible functional differences. The Rockefeller University Press 1985-12-01 /pmc/articles/PMC2187978/ /pubmed/2415655 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Evidence for a shared HLA-A intralocus determinant defined by monoclonal antibody 131
title Evidence for a shared HLA-A intralocus determinant defined by monoclonal antibody 131
title_full Evidence for a shared HLA-A intralocus determinant defined by monoclonal antibody 131
title_fullStr Evidence for a shared HLA-A intralocus determinant defined by monoclonal antibody 131
title_full_unstemmed Evidence for a shared HLA-A intralocus determinant defined by monoclonal antibody 131
title_short Evidence for a shared HLA-A intralocus determinant defined by monoclonal antibody 131
title_sort evidence for a shared hla-a intralocus determinant defined by monoclonal antibody 131
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187978/
https://www.ncbi.nlm.nih.gov/pubmed/2415655

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