Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells

We studied the biological effects of pluripoietin, a human pluripotent hemopoietic colony-stimulating factor (CSF) purified from the 5637 bladder carcinoma cell line. We found that this human CSF appears to be a unique hemopoietic growth factor, differing from interleukin 3 (IL-3) by virtue of its l...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187980/
https://www.ncbi.nlm.nih.gov/pubmed/2999287
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description We studied the biological effects of pluripoietin, a human pluripotent hemopoietic colony-stimulating factor (CSF) purified from the 5637 bladder carcinoma cell line. We found that this human CSF appears to be a unique hemopoietic growth factor, differing from interleukin 3 (IL-3) by virtue of its leukemia differentiating activity in mouse and man, and from mouse granulocyte CSF, which does have differentiation- inducing activity, but lacks pluripoietic activity. In addition, differences from IL-3 were observed in cross-species activity on normal and leukemic cells.
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spelling pubmed-21879802008-04-17 Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells J Exp Med Articles We studied the biological effects of pluripoietin, a human pluripotent hemopoietic colony-stimulating factor (CSF) purified from the 5637 bladder carcinoma cell line. We found that this human CSF appears to be a unique hemopoietic growth factor, differing from interleukin 3 (IL-3) by virtue of its leukemia differentiating activity in mouse and man, and from mouse granulocyte CSF, which does have differentiation- inducing activity, but lacks pluripoietic activity. In addition, differences from IL-3 were observed in cross-species activity on normal and leukemic cells. The Rockefeller University Press 1985-12-01 /pmc/articles/PMC2187980/ /pubmed/2999287 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells
title Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells
title_full Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells
title_fullStr Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells
title_full_unstemmed Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells
title_short Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells
title_sort biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187980/
https://www.ncbi.nlm.nih.gov/pubmed/2999287

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