Identification of three new Ig lambda-like genes in man

Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188038/
https://www.ncbi.nlm.nih.gov/pubmed/3003227
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collection PubMed
description Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies. This study demonstrates that the human lambda gene family is more complex than previously recognized.
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spelling pubmed-21880382008-04-17 Identification of three new Ig lambda-like genes in man J Exp Med Articles Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies. This study demonstrates that the human lambda gene family is more complex than previously recognized. The Rockefeller University Press 1986-02-01 /pmc/articles/PMC2188038/ /pubmed/3003227 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Identification of three new Ig lambda-like genes in man
title Identification of three new Ig lambda-like genes in man
title_full Identification of three new Ig lambda-like genes in man
title_fullStr Identification of three new Ig lambda-like genes in man
title_full_unstemmed Identification of three new Ig lambda-like genes in man
title_short Identification of three new Ig lambda-like genes in man
title_sort identification of three new ig lambda-like genes in man
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188038/
https://www.ncbi.nlm.nih.gov/pubmed/3003227

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