Lack of relationship between serum gp70 levels and the severity of systemic lupus erythematosus in MRL/l mice

In the MRL/l mouse, gp70 apparently plays a role as an autoantigen in the development of SLE. However, while gp70 may be an important pathogenetic element, it is not essential to MRL SLE, since elimination of most of the serum gp70 and virtually all of the immune complex gp70 from MRL/l-low gp70 con...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188041/
https://www.ncbi.nlm.nih.gov/pubmed/3944541
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description In the MRL/l mouse, gp70 apparently plays a role as an autoantigen in the development of SLE. However, while gp70 may be an important pathogenetic element, it is not essential to MRL SLE, since elimination of most of the serum gp70 and virtually all of the immune complex gp70 from MRL/l-low gp70 congenic lines had no observable effect on the course or nature of the disease. Thus, while gp70 in the MRL/l mouse appears to be a convenient autoantigenic target when present in significant levels, in its absence the host appears capable of directing its aberrant immunologic responsiveness elsewhere with undiminished pathogenicity.
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spelling pubmed-21880412008-04-17 Lack of relationship between serum gp70 levels and the severity of systemic lupus erythematosus in MRL/l mice J Exp Med Articles In the MRL/l mouse, gp70 apparently plays a role as an autoantigen in the development of SLE. However, while gp70 may be an important pathogenetic element, it is not essential to MRL SLE, since elimination of most of the serum gp70 and virtually all of the immune complex gp70 from MRL/l-low gp70 congenic lines had no observable effect on the course or nature of the disease. Thus, while gp70 in the MRL/l mouse appears to be a convenient autoantigenic target when present in significant levels, in its absence the host appears capable of directing its aberrant immunologic responsiveness elsewhere with undiminished pathogenicity. The Rockefeller University Press 1986-02-01 /pmc/articles/PMC2188041/ /pubmed/3944541 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Lack of relationship between serum gp70 levels and the severity of systemic lupus erythematosus in MRL/l mice
title Lack of relationship between serum gp70 levels and the severity of systemic lupus erythematosus in MRL/l mice
title_full Lack of relationship between serum gp70 levels and the severity of systemic lupus erythematosus in MRL/l mice
title_fullStr Lack of relationship between serum gp70 levels and the severity of systemic lupus erythematosus in MRL/l mice
title_full_unstemmed Lack of relationship between serum gp70 levels and the severity of systemic lupus erythematosus in MRL/l mice
title_short Lack of relationship between serum gp70 levels and the severity of systemic lupus erythematosus in MRL/l mice
title_sort lack of relationship between serum gp70 levels and the severity of systemic lupus erythematosus in mrl/l mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188041/
https://www.ncbi.nlm.nih.gov/pubmed/3944541

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