Purification and partial characterization of the nephritis strain- associated protein from Streptococcus pyogenes, group A

We report the isolation and purification of the nephritis strain- associated protein (NSAP) first described by Villareal et al. (8). Amino acid analysis, and determination of the first 21 amino-terminal amino acids indicated that this 46 kD protein is a streptokinase. Biochemical analysis confirmed...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188047/
https://www.ncbi.nlm.nih.gov/pubmed/3512759
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description We report the isolation and purification of the nephritis strain- associated protein (NSAP) first described by Villareal et al. (8). Amino acid analysis, and determination of the first 21 amino-terminal amino acids indicated that this 46 kD protein is a streptokinase. Biochemical analysis confirmed that NSAP could act as a plasminogen activator; immunological investigations indicated that NSAP is antigenically different from streptokinase from group C streptococcus, and possibly represents a unique streptokinase. It is this uniqueness that may contribute to the role of NSAP in the pathogenesis of acute poststreptococcal glomerulonephritis.
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spelling pubmed-21880472008-04-17 Purification and partial characterization of the nephritis strain- associated protein from Streptococcus pyogenes, group A J Exp Med Articles We report the isolation and purification of the nephritis strain- associated protein (NSAP) first described by Villareal et al. (8). Amino acid analysis, and determination of the first 21 amino-terminal amino acids indicated that this 46 kD protein is a streptokinase. Biochemical analysis confirmed that NSAP could act as a plasminogen activator; immunological investigations indicated that NSAP is antigenically different from streptokinase from group C streptococcus, and possibly represents a unique streptokinase. It is this uniqueness that may contribute to the role of NSAP in the pathogenesis of acute poststreptococcal glomerulonephritis. The Rockefeller University Press 1986-03-01 /pmc/articles/PMC2188047/ /pubmed/3512759 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Purification and partial characterization of the nephritis strain- associated protein from Streptococcus pyogenes, group A
title Purification and partial characterization of the nephritis strain- associated protein from Streptococcus pyogenes, group A
title_full Purification and partial characterization of the nephritis strain- associated protein from Streptococcus pyogenes, group A
title_fullStr Purification and partial characterization of the nephritis strain- associated protein from Streptococcus pyogenes, group A
title_full_unstemmed Purification and partial characterization of the nephritis strain- associated protein from Streptococcus pyogenes, group A
title_short Purification and partial characterization of the nephritis strain- associated protein from Streptococcus pyogenes, group A
title_sort purification and partial characterization of the nephritis strain- associated protein from streptococcus pyogenes, group a
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188047/
https://www.ncbi.nlm.nih.gov/pubmed/3512759

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