Thy-1+ and Thy-1- natural killer cells. Only Thy-1- natural killer cells suppress dendritic cells

Cells enriched for NK activity (poly I:C induced, x-ray resistant, and nonadherent), include two phenotypically and functionally different populations. Both populations of NK cells are AGM1+, Ly-1.1-, Ly-2.1-, Ia-, and have the morphology of large granular lymphocytes. One population, however, is Th...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188070/
https://www.ncbi.nlm.nih.gov/pubmed/3485171
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collection PubMed
description Cells enriched for NK activity (poly I:C induced, x-ray resistant, and nonadherent), include two phenotypically and functionally different populations. Both populations of NK cells are AGM1+, Ly-1.1-, Ly-2.1-, Ia-, and have the morphology of large granular lymphocytes. One population, however, is Thy-1+ while the second population is Thy-1-. Thy-1+ NK cells lyse YAC-1 and P815 target cells; Thy-1- NK cells lyse YAC-1 but not P815 target cells. The FACS was used to obtain homogeneous populations of Thy-1+ and Thy-1- NK cells, which retain high cytotoxicity. While Thy-1- NK cells suppress the antibody response in vitro by suppressing or eliminating DC, Thy-1+ NK cells do not suppress antibody responses in vitro.
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spelling pubmed-21880702008-04-17 Thy-1+ and Thy-1- natural killer cells. Only Thy-1- natural killer cells suppress dendritic cells J Exp Med Articles Cells enriched for NK activity (poly I:C induced, x-ray resistant, and nonadherent), include two phenotypically and functionally different populations. Both populations of NK cells are AGM1+, Ly-1.1-, Ly-2.1-, Ia-, and have the morphology of large granular lymphocytes. One population, however, is Thy-1+ while the second population is Thy-1-. Thy-1+ NK cells lyse YAC-1 and P815 target cells; Thy-1- NK cells lyse YAC-1 but not P815 target cells. The FACS was used to obtain homogeneous populations of Thy-1+ and Thy-1- NK cells, which retain high cytotoxicity. While Thy-1- NK cells suppress the antibody response in vitro by suppressing or eliminating DC, Thy-1+ NK cells do not suppress antibody responses in vitro. The Rockefeller University Press 1986-04-01 /pmc/articles/PMC2188070/ /pubmed/3485171 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Thy-1+ and Thy-1- natural killer cells. Only Thy-1- natural killer cells suppress dendritic cells
title Thy-1+ and Thy-1- natural killer cells. Only Thy-1- natural killer cells suppress dendritic cells
title_full Thy-1+ and Thy-1- natural killer cells. Only Thy-1- natural killer cells suppress dendritic cells
title_fullStr Thy-1+ and Thy-1- natural killer cells. Only Thy-1- natural killer cells suppress dendritic cells
title_full_unstemmed Thy-1+ and Thy-1- natural killer cells. Only Thy-1- natural killer cells suppress dendritic cells
title_short Thy-1+ and Thy-1- natural killer cells. Only Thy-1- natural killer cells suppress dendritic cells
title_sort thy-1+ and thy-1- natural killer cells. only thy-1- natural killer cells suppress dendritic cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188070/
https://www.ncbi.nlm.nih.gov/pubmed/3485171

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