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Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor
Human endothelial cells activated with IL-1 express a surface membrane- oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibi...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1986
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188126/ https://www.ncbi.nlm.nih.gov/pubmed/3086483 |
| _version_ | 1782146335057641472 |
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| collection | PubMed |
| description | Human endothelial cells activated with IL-1 express a surface membrane- oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibitor. This array of IL-1-induced activities shifts the balance at the endothelial cell surface to a prothrombotic influence and may reflect an early response of the blood vessel wall to injury. |
| format | Text |
| id | pubmed-2188126 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1986 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-21881262008-04-17 Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor J Exp Med Articles Human endothelial cells activated with IL-1 express a surface membrane- oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibitor. This array of IL-1-induced activities shifts the balance at the endothelial cell surface to a prothrombotic influence and may reflect an early response of the blood vessel wall to injury. The Rockefeller University Press 1986-06-01 /pmc/articles/PMC2188126/ /pubmed/3086483 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Articles Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor |
| title | Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor |
| title_full | Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor |
| title_fullStr | Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor |
| title_full_unstemmed | Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor |
| title_short | Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor |
| title_sort | interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor |
| topic | Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188126/ https://www.ncbi.nlm.nih.gov/pubmed/3086483 |