Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis

Human protectin (CD59) is an 18-20-kD membrane glycoprotein that restricts lysis of human erythrocytes and leukocytes by homologous complement. By directly incorporating protectin into membranes of heterologous cells we observed that protectin did not prevent perforin- mediated killing, whereas comp...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188136/
https://www.ncbi.nlm.nih.gov/pubmed/1694224
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collection PubMed
description Human protectin (CD59) is an 18-20-kD membrane glycoprotein that restricts lysis of human erythrocytes and leukocytes by homologous complement. By directly incorporating protectin into membranes of heterologous cells we observed that protectin did not prevent perforin- mediated killing, whereas complement killing was effectively restricted. Further, no significant enhancement of cell-mediated killing or target killing by purified perforin was observed with anti- protectin antibodies. Thus, in contrast with complement lysis, restriction of lysis by protectin does not apply to cell-mediated killing.
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spelling pubmed-21881362008-04-17 Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis J Exp Med Articles Human protectin (CD59) is an 18-20-kD membrane glycoprotein that restricts lysis of human erythrocytes and leukocytes by homologous complement. By directly incorporating protectin into membranes of heterologous cells we observed that protectin did not prevent perforin- mediated killing, whereas complement killing was effectively restricted. Further, no significant enhancement of cell-mediated killing or target killing by purified perforin was observed with anti- protectin antibodies. Thus, in contrast with complement lysis, restriction of lysis by protectin does not apply to cell-mediated killing. The Rockefeller University Press 1990-07-01 /pmc/articles/PMC2188136/ /pubmed/1694224 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis
title Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis
title_full Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis
title_fullStr Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis
title_full_unstemmed Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis
title_short Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis
title_sort human protectin (cd59), an 18-20-kd homologous complement restriction factor, does not restrict perforin-mediated lysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188136/
https://www.ncbi.nlm.nih.gov/pubmed/1694224

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