Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients

Production of the eosinophilogenic cytokines interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), and IL-5 by mitogen-stimulated peripheral blood mononuclear cells was compared between 11 noneosinophilic individuals and seven patients with helminth- induced eosinophilia....

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188151/
https://www.ncbi.nlm.nih.gov/pubmed/2193099
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collection PubMed
description Production of the eosinophilogenic cytokines interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), and IL-5 by mitogen-stimulated peripheral blood mononuclear cells was compared between 11 noneosinophilic individuals and seven patients with helminth- induced eosinophilia. Both the kinetics and quantities of IL-3 and GM- CSF were similar in the two groups. In contrast, IL-5 production at both the protein and the mRNA level was markedly greater in the eosinophilic patients, an observation suggesting that IL-5 may be particularly important in mediating the selective eosinophilia seen in filarial and other helminth infections.
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spelling pubmed-21881512008-04-17 Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients J Exp Med Articles Production of the eosinophilogenic cytokines interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), and IL-5 by mitogen-stimulated peripheral blood mononuclear cells was compared between 11 noneosinophilic individuals and seven patients with helminth- induced eosinophilia. Both the kinetics and quantities of IL-3 and GM- CSF were similar in the two groups. In contrast, IL-5 production at both the protein and the mRNA level was markedly greater in the eosinophilic patients, an observation suggesting that IL-5 may be particularly important in mediating the selective eosinophilia seen in filarial and other helminth infections. The Rockefeller University Press 1990-07-01 /pmc/articles/PMC2188151/ /pubmed/2193099 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients
title Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients
title_full Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients
title_fullStr Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients
title_full_unstemmed Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients
title_short Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients
title_sort regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188151/
https://www.ncbi.nlm.nih.gov/pubmed/2193099

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