An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination

The effects of cyclosporin A (CsA) on influencing the intrathymic clonal deletion were investigated by using our established thymic stromal cell clone with capacities to express Ia antigens and to produce a unique T cell growth factor. The following were revealed: (a) T cell clone with a given speci...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188159/
https://www.ncbi.nlm.nih.gov/pubmed/2113566
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description The effects of cyclosporin A (CsA) on influencing the intrathymic clonal deletion were investigated by using our established thymic stromal cell clone with capacities to express Ia antigens and to produce a unique T cell growth factor. The following were revealed: (a) T cell clone with a given specificity was killed on the Ia+ stromal cell monolayer in the presence of the relevant antigens, a process depending on T cell receptor (TCR) stimulation; and (b) CsA allowed the T cell clone to continuously proliferate even during TCR stimulation by virtue of the stromal cell-derived T cell growth factor. This paper describes an in vitro model of a mechanism by which CsA is responsible for the generation of normally "forbidden" T cell clones.
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spelling pubmed-21881592008-04-17 An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination J Exp Med Articles The effects of cyclosporin A (CsA) on influencing the intrathymic clonal deletion were investigated by using our established thymic stromal cell clone with capacities to express Ia antigens and to produce a unique T cell growth factor. The following were revealed: (a) T cell clone with a given specificity was killed on the Ia+ stromal cell monolayer in the presence of the relevant antigens, a process depending on T cell receptor (TCR) stimulation; and (b) CsA allowed the T cell clone to continuously proliferate even during TCR stimulation by virtue of the stromal cell-derived T cell growth factor. This paper describes an in vitro model of a mechanism by which CsA is responsible for the generation of normally "forbidden" T cell clones. The Rockefeller University Press 1990-07-01 /pmc/articles/PMC2188159/ /pubmed/2113566 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination
title An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination
title_full An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination
title_fullStr An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination
title_full_unstemmed An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination
title_short An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination
title_sort in vitro model for cyclosporin a-induced interference of intrathymic clonal elimination
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188159/
https://www.ncbi.nlm.nih.gov/pubmed/2113566

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