Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins

We monitored the APC function of cells taken from the spleen and peritoneal cavity of mice that had been given protein antigens via the intravenous or intraperitoneal routes. Using the mAb 33D1 and N418 to negatively and positively select dendritic cells, we obtained evidence that dendritic cells ar...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188167/
https://www.ncbi.nlm.nih.gov/pubmed/1694226
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collection PubMed
description We monitored the APC function of cells taken from the spleen and peritoneal cavity of mice that had been given protein antigens via the intravenous or intraperitoneal routes. Using the mAb 33D1 and N418 to negatively and positively select dendritic cells, we obtained evidence that dendritic cells are the main cell type in spleen that carries the protein in a form that is immunogenic for antigen-specific T cells. In vivo pulsed macrophages were not immunogenic and did not appear capable of transferring peptide fragments to dendritic cells.
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spelling pubmed-21881672008-04-17 Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins J Exp Med Articles We monitored the APC function of cells taken from the spleen and peritoneal cavity of mice that had been given protein antigens via the intravenous or intraperitoneal routes. Using the mAb 33D1 and N418 to negatively and positively select dendritic cells, we obtained evidence that dendritic cells are the main cell type in spleen that carries the protein in a form that is immunogenic for antigen-specific T cells. In vivo pulsed macrophages were not immunogenic and did not appear capable of transferring peptide fragments to dendritic cells. The Rockefeller University Press 1990-07-01 /pmc/articles/PMC2188167/ /pubmed/1694226 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins
title Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins
title_full Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins
title_fullStr Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins
title_full_unstemmed Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins
title_short Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins
title_sort dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188167/
https://www.ncbi.nlm.nih.gov/pubmed/1694226

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