Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization

Using monoclonal antibodies identifying all gamma/delta and alpha/beta T cell receptors in cytofluorometric analysis, we have compared the composition of intestinal intraepithelial lymphocytes (i-IEL) in euthymic and athymic germ-free (GF) and conventional (SPF) mice. The results show a marked influ...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188170/
https://www.ncbi.nlm.nih.gov/pubmed/2141628
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description Using monoclonal antibodies identifying all gamma/delta and alpha/beta T cell receptors in cytofluorometric analysis, we have compared the composition of intestinal intraepithelial lymphocytes (i-IEL) in euthymic and athymic germ-free (GF) and conventional (SPF) mice. The results show a marked influence of microbial colonization in the numbers of single-positive (CD4+ or CD8+) alpha/beta i-IEL, but little effect in the pool size or characteristics of gamma/delta i-IEL. In young athymic mice, virtually no alpha/beta i-IEL are detected, while considerable numbers of gamma/delta i-IEL remain, though reduced in GF animals.
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spelling pubmed-21881702008-04-17 Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization J Exp Med Articles Using monoclonal antibodies identifying all gamma/delta and alpha/beta T cell receptors in cytofluorometric analysis, we have compared the composition of intestinal intraepithelial lymphocytes (i-IEL) in euthymic and athymic germ-free (GF) and conventional (SPF) mice. The results show a marked influence of microbial colonization in the numbers of single-positive (CD4+ or CD8+) alpha/beta i-IEL, but little effect in the pool size or characteristics of gamma/delta i-IEL. In young athymic mice, virtually no alpha/beta i-IEL are detected, while considerable numbers of gamma/delta i-IEL remain, though reduced in GF animals. The Rockefeller University Press 1990-07-01 /pmc/articles/PMC2188170/ /pubmed/2141628 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization
title Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization
title_full Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization
title_fullStr Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization
title_full_unstemmed Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization
title_short Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization
title_sort localization of gamma/delta t cells to the intestinal epithelium is independent of normal microbial colonization
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188170/
https://www.ncbi.nlm.nih.gov/pubmed/2141628

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