Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens

CD3+ T lymphocytes expressing neither CD4 nor CD8 antigens exist in normal human peripheral blood in low frequency (approximately 3% of lymphocytes). The CD3+,4-,8- phenotype was stably maintained after in vitro culture in IL-2. Culture of CD3+,4-,8- cells in only rIL-2 generated cytotoxic T cells t...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188194/
https://www.ncbi.nlm.nih.gov/pubmed/2425030
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collection PubMed
description CD3+ T lymphocytes expressing neither CD4 nor CD8 antigens exist in normal human peripheral blood in low frequency (approximately 3% of lymphocytes). The CD3+,4-,8- phenotype was stably maintained after in vitro culture in IL-2. Culture of CD3+,4-,8- cells in only rIL-2 generated cytotoxic T cells that lysed NK-sensitive and NK-insensitive tumor cell targets without MHC restriction. These experiments clearly show that phenotypically and functionally competent T cells expressing neither CD4 nor CD8 are present in normal peripheral blood.
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spelling pubmed-21881942008-04-17 Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens J Exp Med Articles CD3+ T lymphocytes expressing neither CD4 nor CD8 antigens exist in normal human peripheral blood in low frequency (approximately 3% of lymphocytes). The CD3+,4-,8- phenotype was stably maintained after in vitro culture in IL-2. Culture of CD3+,4-,8- cells in only rIL-2 generated cytotoxic T cells that lysed NK-sensitive and NK-insensitive tumor cell targets without MHC restriction. These experiments clearly show that phenotypically and functionally competent T cells expressing neither CD4 nor CD8 are present in normal peripheral blood. The Rockefeller University Press 1986-07-01 /pmc/articles/PMC2188194/ /pubmed/2425030 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens
title Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens
title_full Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens
title_fullStr Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens
title_full_unstemmed Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens
title_short Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens
title_sort human cd3+ t lymphocytes that express neither cd4 nor cd8 antigens
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188194/
https://www.ncbi.nlm.nih.gov/pubmed/2425030

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