Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency

Intraperitoneal administration of group A streptococcal cell walls to Lewis rats induces a chronic arthritis, whereas the Fischer strain is resistant to the development of the lesion. Spleen cells from cell wall- treated rats (Lewis and Fischer) are deficient in the synthesis of IL- 2. Using an mAb...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188202/
https://www.ncbi.nlm.nih.gov/pubmed/3088198
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collection PubMed
description Intraperitoneal administration of group A streptococcal cell walls to Lewis rats induces a chronic arthritis, whereas the Fischer strain is resistant to the development of the lesion. Spleen cells from cell wall- treated rats (Lewis and Fischer) are deficient in the synthesis of IL- 2. Using an mAb directed against the rat IL-2-R, the present studies indicate that the expression of IL-2-R on spleens of cell wall-treated rats is normal. However, the addition of exogenous IL-2 to spleen cells cultured with Con A does not stimulate the mitogenic response.
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spelling pubmed-21882022008-04-17 Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency J Exp Med Articles Intraperitoneal administration of group A streptococcal cell walls to Lewis rats induces a chronic arthritis, whereas the Fischer strain is resistant to the development of the lesion. Spleen cells from cell wall- treated rats (Lewis and Fischer) are deficient in the synthesis of IL- 2. Using an mAb directed against the rat IL-2-R, the present studies indicate that the expression of IL-2-R on spleens of cell wall-treated rats is normal. However, the addition of exogenous IL-2 to spleen cells cultured with Con A does not stimulate the mitogenic response. The Rockefeller University Press 1986-07-01 /pmc/articles/PMC2188202/ /pubmed/3088198 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency
title Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency
title_full Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency
title_fullStr Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency
title_full_unstemmed Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency
title_short Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency
title_sort administration of group a streptococcal cell walls to rats induces an interleukin 2 deficiency
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188202/
https://www.ncbi.nlm.nih.gov/pubmed/3088198

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