Lack of expression of the VHS107 gene family in the lipopolysaccharide- sensitive B cell subset of X-linked immunodeficiency-defective mice

The expression of the VH T15 gene product was analyzed in the sera and in the supernatants of polyclonally activated B cells of X-linked immunodeficient (xid) mice. We found that defective males, contrary to normal females, do not express the VH T15 gene product even on antibodies devoid of anti-PC...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188206/
https://www.ncbi.nlm.nih.gov/pubmed/3088200
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collection PubMed
description The expression of the VH T15 gene product was analyzed in the sera and in the supernatants of polyclonally activated B cells of X-linked immunodeficient (xid) mice. We found that defective males, contrary to normal females, do not express the VH T15 gene product even on antibodies devoid of anti-PC specificity. RNA analysis of polyclonally activated cells with VH specific probes revealed that xid-defective B cells do not express the entire S107 or part of the J606 VH family. Members of the J558 family, on the other hand, are equally well expressed among defective males and normal female B cells. These results strongly suggest that VH families are asymmetrically represented among B cell subsets.
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spelling pubmed-21882062008-04-17 Lack of expression of the VHS107 gene family in the lipopolysaccharide- sensitive B cell subset of X-linked immunodeficiency-defective mice J Exp Med Articles The expression of the VH T15 gene product was analyzed in the sera and in the supernatants of polyclonally activated B cells of X-linked immunodeficient (xid) mice. We found that defective males, contrary to normal females, do not express the VH T15 gene product even on antibodies devoid of anti-PC specificity. RNA analysis of polyclonally activated cells with VH specific probes revealed that xid-defective B cells do not express the entire S107 or part of the J606 VH family. Members of the J558 family, on the other hand, are equally well expressed among defective males and normal female B cells. These results strongly suggest that VH families are asymmetrically represented among B cell subsets. The Rockefeller University Press 1986-07-01 /pmc/articles/PMC2188206/ /pubmed/3088200 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Lack of expression of the VHS107 gene family in the lipopolysaccharide- sensitive B cell subset of X-linked immunodeficiency-defective mice
title Lack of expression of the VHS107 gene family in the lipopolysaccharide- sensitive B cell subset of X-linked immunodeficiency-defective mice
title_full Lack of expression of the VHS107 gene family in the lipopolysaccharide- sensitive B cell subset of X-linked immunodeficiency-defective mice
title_fullStr Lack of expression of the VHS107 gene family in the lipopolysaccharide- sensitive B cell subset of X-linked immunodeficiency-defective mice
title_full_unstemmed Lack of expression of the VHS107 gene family in the lipopolysaccharide- sensitive B cell subset of X-linked immunodeficiency-defective mice
title_short Lack of expression of the VHS107 gene family in the lipopolysaccharide- sensitive B cell subset of X-linked immunodeficiency-defective mice
title_sort lack of expression of the vhs107 gene family in the lipopolysaccharide- sensitive b cell subset of x-linked immunodeficiency-defective mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188206/
https://www.ncbi.nlm.nih.gov/pubmed/3088200

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