Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells

Lyt-2+ T cell clones were established from Listeria monocytogenes- infected mice. The clones secreted IFN-gamma after stimulation with spleen cells from L. monocytogenes-infected mice plus IL-2. Spleen cells from normal mice were not stimulatory. Furthermore, cloned T cells lysed L. monocytogenes-in...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188209/
https://www.ncbi.nlm.nih.gov/pubmed/3088201
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collection PubMed
description Lyt-2+ T cell clones were established from Listeria monocytogenes- infected mice. The clones secreted IFN-gamma after stimulation with spleen cells from L. monocytogenes-infected mice plus IL-2. Spleen cells from normal mice were not stimulatory. Furthermore, cloned T cells lysed L. monocytogenes-infected macrophages. Cytolysis was antigen-specific and H-2K-restricted. These findings suggest a role for specific cytotoxic T cells in the immune response to intracellular bacteria.
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spelling pubmed-21882092008-04-17 Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells J Exp Med Articles Lyt-2+ T cell clones were established from Listeria monocytogenes- infected mice. The clones secreted IFN-gamma after stimulation with spleen cells from L. monocytogenes-infected mice plus IL-2. Spleen cells from normal mice were not stimulatory. Furthermore, cloned T cells lysed L. monocytogenes-infected macrophages. Cytolysis was antigen-specific and H-2K-restricted. These findings suggest a role for specific cytotoxic T cells in the immune response to intracellular bacteria. The Rockefeller University Press 1986-07-01 /pmc/articles/PMC2188209/ /pubmed/3088201 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells
title Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells
title_full Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells
title_fullStr Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells
title_full_unstemmed Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells
title_short Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells
title_sort listeria monocytogenes-reactive t lymphocyte clones with cytolytic activity against infected target cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188209/
https://www.ncbi.nlm.nih.gov/pubmed/3088201

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