An HLA-D region restriction fragment length polymorphism associated with celiac disease

This study is the first to describe a molecular marker that distinguishes the celiac disease HLA-D region haplotype from a serologically identical haplotype in unaffected controls. Using a DQ beta chain cDNA probe and the restriction endonuclease Rsa I, we have detected a polymorphic 4.0 kb fragment...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188220/
https://www.ncbi.nlm.nih.gov/pubmed/3014038
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description This study is the first to describe a molecular marker that distinguishes the celiac disease HLA-D region haplotype from a serologically identical haplotype in unaffected controls. Using a DQ beta chain cDNA probe and the restriction endonuclease Rsa I, we have detected a polymorphic 4.0 kb fragment which, in DQw2 individuals, is associated with a 40-fold increased relative risk of developing celiac disease. This finding should permit the identification of the celiac disease susceptibility gene(s) in the HLA-D region and facilitate a more precise dissection of the molecular and immunogenetic mechanisms involved in the pathogenesis of that disease.
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spelling pubmed-21882202008-04-17 An HLA-D region restriction fragment length polymorphism associated with celiac disease J Exp Med Articles This study is the first to describe a molecular marker that distinguishes the celiac disease HLA-D region haplotype from a serologically identical haplotype in unaffected controls. Using a DQ beta chain cDNA probe and the restriction endonuclease Rsa I, we have detected a polymorphic 4.0 kb fragment which, in DQw2 individuals, is associated with a 40-fold increased relative risk of developing celiac disease. This finding should permit the identification of the celiac disease susceptibility gene(s) in the HLA-D region and facilitate a more precise dissection of the molecular and immunogenetic mechanisms involved in the pathogenesis of that disease. The Rockefeller University Press 1986-07-01 /pmc/articles/PMC2188220/ /pubmed/3014038 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
An HLA-D region restriction fragment length polymorphism associated with celiac disease
title An HLA-D region restriction fragment length polymorphism associated with celiac disease
title_full An HLA-D region restriction fragment length polymorphism associated with celiac disease
title_fullStr An HLA-D region restriction fragment length polymorphism associated with celiac disease
title_full_unstemmed An HLA-D region restriction fragment length polymorphism associated with celiac disease
title_short An HLA-D region restriction fragment length polymorphism associated with celiac disease
title_sort hla-d region restriction fragment length polymorphism associated with celiac disease
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188220/
https://www.ncbi.nlm.nih.gov/pubmed/3014038

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