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Blockade of clearance of immune complexes by an anti-F(cγ) receptor monoclonal antibody

Clearance of immune complexes by the mononuclear phagocyte system is important for maintaining normal host defenses against bacterial and viral assault (1), but also contributes to the pathogenesis of a variety of immune- mediated diseases . For example, removal from the circulation of IgG-coated er...

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Autores principales: Clarkson, SB, Kimberly, RP, Valinsky, JE, Witmer, MD, Bussel, JB, Nachman, RL, Unkeless, JC
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188226/
https://www.ncbi.nlm.nih.gov/pubmed/2941515
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author Clarkson, SB
Kimberly, RP
Valinsky, JE
Witmer, MD
Bussel, JB
Nachman, RL
Unkeless, JC
author_facet Clarkson, SB
Kimberly, RP
Valinsky, JE
Witmer, MD
Bussel, JB
Nachman, RL
Unkeless, JC
author_sort Clarkson, SB
collection PubMed
description Clearance of immune complexes by the mononuclear phagocyte system is important for maintaining normal host defenses against bacterial and viral assault (1), but also contributes to the pathogenesis of a variety of immune- mediated diseases . For example, removal from the circulation of IgG-coated erythrocytes and platelets by the MPS is the sine qua non of immune-mediated cytopenias (2, 3). On the other hand, abnormally decreased removal by the MPS of smaller, soluble immune complexes may play a role in the pathogenesis of immune complex-mediated tissue damage found in such autoimmune diseases as SLE (4). Although the physicochemical nature and the size of immune complexes can influence rates of clearance and sites of deposition (reviewed in 5), interactions between immune complexes and the MPS in vivo are poorly understood. The inability to directly measure binding or internalization of immune complexes by cells in the liver and spleen has made the analysis of the molecular basis of immune complex clearance very difficult . Receptors for the Fc portion of IgG (FcγR) and for complement (CR) undoubtedly play a role in the removal of immune complexes, but the relative importance of these receptors is not known.
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spelling pubmed-21882262008-04-17 Blockade of clearance of immune complexes by an anti-F(cγ) receptor monoclonal antibody Clarkson, SB Kimberly, RP Valinsky, JE Witmer, MD Bussel, JB Nachman, RL Unkeless, JC J Exp Med Articles Clearance of immune complexes by the mononuclear phagocyte system is important for maintaining normal host defenses against bacterial and viral assault (1), but also contributes to the pathogenesis of a variety of immune- mediated diseases . For example, removal from the circulation of IgG-coated erythrocytes and platelets by the MPS is the sine qua non of immune-mediated cytopenias (2, 3). On the other hand, abnormally decreased removal by the MPS of smaller, soluble immune complexes may play a role in the pathogenesis of immune complex-mediated tissue damage found in such autoimmune diseases as SLE (4). Although the physicochemical nature and the size of immune complexes can influence rates of clearance and sites of deposition (reviewed in 5), interactions between immune complexes and the MPS in vivo are poorly understood. The inability to directly measure binding or internalization of immune complexes by cells in the liver and spleen has made the analysis of the molecular basis of immune complex clearance very difficult . Receptors for the Fc portion of IgG (FcγR) and for complement (CR) undoubtedly play a role in the removal of immune complexes, but the relative importance of these receptors is not known. The Rockefeller University Press 1986-08-01 /pmc/articles/PMC2188226/ /pubmed/2941515 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Clarkson, SB
Kimberly, RP
Valinsky, JE
Witmer, MD
Bussel, JB
Nachman, RL
Unkeless, JC
Blockade of clearance of immune complexes by an anti-F(cγ) receptor monoclonal antibody
title Blockade of clearance of immune complexes by an anti-F(cγ) receptor monoclonal antibody
title_full Blockade of clearance of immune complexes by an anti-F(cγ) receptor monoclonal antibody
title_fullStr Blockade of clearance of immune complexes by an anti-F(cγ) receptor monoclonal antibody
title_full_unstemmed Blockade of clearance of immune complexes by an anti-F(cγ) receptor monoclonal antibody
title_short Blockade of clearance of immune complexes by an anti-F(cγ) receptor monoclonal antibody
title_sort blockade of clearance of immune complexes by an anti-f(cγ) receptor monoclonal antibody
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188226/
https://www.ncbi.nlm.nih.gov/pubmed/2941515
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