A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3

The 38 kD molecule is noncovalently associated with beta 2 microglobulin (beta 2m)-free HLA heavy chain-like molecule, and thus forms a second heterodimer distinct from the clonotypic alpha/beta T cell receptor expressed by the same clone of leukemia cells. This second heterodimer (38 kD/HLA) is var...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188241/
https://www.ncbi.nlm.nih.gov/pubmed/3088207
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collection PubMed
description The 38 kD molecule is noncovalently associated with beta 2 microglobulin (beta 2m)-free HLA heavy chain-like molecule, and thus forms a second heterodimer distinct from the clonotypic alpha/beta T cell receptor expressed by the same clone of leukemia cells. This second heterodimer (38 kD/HLA) is variably expressed and appears to be associated with the T3 molecule. We suggest, therefore, that it has a functional role in T cell activation.
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spelling pubmed-21882412008-04-17 A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3 J Exp Med Articles The 38 kD molecule is noncovalently associated with beta 2 microglobulin (beta 2m)-free HLA heavy chain-like molecule, and thus forms a second heterodimer distinct from the clonotypic alpha/beta T cell receptor expressed by the same clone of leukemia cells. This second heterodimer (38 kD/HLA) is variably expressed and appears to be associated with the T3 molecule. We suggest, therefore, that it has a functional role in T cell activation. The Rockefeller University Press 1986-08-01 /pmc/articles/PMC2188241/ /pubmed/3088207 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3
title A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3
title_full A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3
title_fullStr A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3
title_full_unstemmed A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3
title_short A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3
title_sort new hla-linked t cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with t3
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188241/
https://www.ncbi.nlm.nih.gov/pubmed/3088207

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