IgG2a restriction of murine antibodies elicited by viral infections

The isotypic distribution of IgG antibodies was determined in the serum of mice after infection with a panel of RNA and DNA viruses representative of 11 different genera. The antiviral response induced by all these viruses showed a striking preponderance of the IgG2a subclass whatever the strain of...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188250/
https://www.ncbi.nlm.nih.gov/pubmed/3794607
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description The isotypic distribution of IgG antibodies was determined in the serum of mice after infection with a panel of RNA and DNA viruses representative of 11 different genera. The antiviral response induced by all these viruses showed a striking preponderance of the IgG2a subclass whatever the strain of mice tested or the time elapsed after infection. Together with the predominance of IgG1 in antiprotein and of IgG3 in anticarbohydrate response, this IgG2a restriction of antiviral antibodies strongly suggests the existence of highly specific mechanisms for the regulation of individual subclasses in the mouse.
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spelling pubmed-21882502008-04-17 IgG2a restriction of murine antibodies elicited by viral infections J Exp Med Articles The isotypic distribution of IgG antibodies was determined in the serum of mice after infection with a panel of RNA and DNA viruses representative of 11 different genera. The antiviral response induced by all these viruses showed a striking preponderance of the IgG2a subclass whatever the strain of mice tested or the time elapsed after infection. Together with the predominance of IgG1 in antiprotein and of IgG3 in anticarbohydrate response, this IgG2a restriction of antiviral antibodies strongly suggests the existence of highly specific mechanisms for the regulation of individual subclasses in the mouse. The Rockefeller University Press 1987-01-01 /pmc/articles/PMC2188250/ /pubmed/3794607 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
IgG2a restriction of murine antibodies elicited by viral infections
title IgG2a restriction of murine antibodies elicited by viral infections
title_full IgG2a restriction of murine antibodies elicited by viral infections
title_fullStr IgG2a restriction of murine antibodies elicited by viral infections
title_full_unstemmed IgG2a restriction of murine antibodies elicited by viral infections
title_short IgG2a restriction of murine antibodies elicited by viral infections
title_sort igg2a restriction of murine antibodies elicited by viral infections
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188250/
https://www.ncbi.nlm.nih.gov/pubmed/3794607

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