The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes

A monoclonal antibody called MRC OX-44 is described that labels all myeloid cells and peripheral lymphoid cells but only 12% of thymocytes. The OX-44+ thymic cells include most if not all cells found in the medulla but only a small fraction of the cortical cells. Together with CD4 and CD8 antigens,...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188261/
https://www.ncbi.nlm.nih.gov/pubmed/3098892
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collection PubMed
description A monoclonal antibody called MRC OX-44 is described that labels all myeloid cells and peripheral lymphoid cells but only 12% of thymocytes. The OX-44+ thymic cells include most if not all cells found in the medulla but only a small fraction of the cortical cells. Together with CD4 and CD8 antigens, seven subsets of thymic cell were defined and it was notable that most CD4- CD8- cells were OX-44+ whereas almost all CD4+ CD8+ cells were OX-44-. In functional tests, the OX-44+ cells accounted for all proliferation by thymocytes when stimulated by allogeneic spleen cells or concanavalin A plus growth factors and OX-44- cells were completely negative in these assays. Also, in tests for thymopoiesis after intra-thymic injection of cells, all activity was OX- 44+. It seems possible that the OX-44+ set may include all functionally relevant cells in the rat thymus.
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spelling pubmed-21882612008-04-17 The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes J Exp Med Articles A monoclonal antibody called MRC OX-44 is described that labels all myeloid cells and peripheral lymphoid cells but only 12% of thymocytes. The OX-44+ thymic cells include most if not all cells found in the medulla but only a small fraction of the cortical cells. Together with CD4 and CD8 antigens, seven subsets of thymic cell were defined and it was notable that most CD4- CD8- cells were OX-44+ whereas almost all CD4+ CD8+ cells were OX-44-. In functional tests, the OX-44+ cells accounted for all proliferation by thymocytes when stimulated by allogeneic spleen cells or concanavalin A plus growth factors and OX-44- cells were completely negative in these assays. Also, in tests for thymopoiesis after intra-thymic injection of cells, all activity was OX- 44+. It seems possible that the OX-44+ set may include all functionally relevant cells in the rat thymus. The Rockefeller University Press 1987-01-01 /pmc/articles/PMC2188261/ /pubmed/3098892 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes
title The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes
title_full The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes
title_fullStr The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes
title_full_unstemmed The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes
title_short The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes
title_sort mrc ox-44 antigen marks a functionally relevant subset among rat thymocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188261/
https://www.ncbi.nlm.nih.gov/pubmed/3098892

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