Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS)

Athymic nu/nu mice were found to be resistant to the immunodeficiency disease and lethality induced in normal mice by the injection of the LP- BM5 mixture of murine retroviruses (LP-BM5 MuLV). Susceptibility to disease induction was reconstituted by injection of nu/nu mice with purified, mature T ly...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188367/
https://www.ncbi.nlm.nih.gov/pubmed/3035057
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description Athymic nu/nu mice were found to be resistant to the immunodeficiency disease and lethality induced in normal mice by the injection of the LP- BM5 mixture of murine retroviruses (LP-BM5 MuLV). Susceptibility to disease induction was reconstituted by injection of nu/nu mice with purified, mature T lymphocytes. The extent of viral replication of both the ecotropic and mink cell focus forming (MCF) components of LP-BM5 MuLV was equivalent in both nu/nu and normal animals. Retrovirally- induced immunodeficiency disease in mice (MAIDS) is thus dependent upon the presence of functional T lymphocytes, and high virus titers in athymic mice have little or no effect on the immune system.
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spelling pubmed-21883672008-04-17 Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS) J Exp Med Articles Athymic nu/nu mice were found to be resistant to the immunodeficiency disease and lethality induced in normal mice by the injection of the LP- BM5 mixture of murine retroviruses (LP-BM5 MuLV). Susceptibility to disease induction was reconstituted by injection of nu/nu mice with purified, mature T lymphocytes. The extent of viral replication of both the ecotropic and mink cell focus forming (MCF) components of LP-BM5 MuLV was equivalent in both nu/nu and normal animals. Retrovirally- induced immunodeficiency disease in mice (MAIDS) is thus dependent upon the presence of functional T lymphocytes, and high virus titers in athymic mice have little or no effect on the immune system. The Rockefeller University Press 1987-06-01 /pmc/articles/PMC2188367/ /pubmed/3035057 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS)
title Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS)
title_full Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS)
title_fullStr Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS)
title_full_unstemmed Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS)
title_short Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS)
title_sort functional t lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (maids)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188367/
https://www.ncbi.nlm.nih.gov/pubmed/3035057

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