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Regulation of colony-stimulating factor 1 during pregnancy
Pregnancy results in an elevation in serum and tissue concentrations of the mononuclear phagocytic growth factor, CSF-1 (colony-stimulating factor 1). These increases are associated with an increase in the number of monocytes in the circulation, and with increases in the number of splenic macrophage...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1986
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188388/ https://www.ncbi.nlm.nih.gov/pubmed/3489064 |
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collection | PubMed |
description | Pregnancy results in an elevation in serum and tissue concentrations of the mononuclear phagocytic growth factor, CSF-1 (colony-stimulating factor 1). These increases are associated with an increase in the number of monocytes in the circulation, and with increases in the number of splenic macrophage precursors. In contrast to the approximately 2-fold elevation of the CSF-1 concentrations in serum and most tissues, pregnancy results in a 1,000-fold increase in the concentration of uterine CSF-1. The roughly fivefold elevation in uterine CSF-1 concentration observed at day 5 of pregnancy could be mimicked by administration of chorionic gonadotrophin in intact but not ovariectomized mice. These dramatic changes in uterine CSF-1 concentrations may indicate a role for CSF-1 in the regulation of nonmononuclear phagocytic cell types. |
format | Text |
id | pubmed-2188388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1986 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21883882008-04-17 Regulation of colony-stimulating factor 1 during pregnancy J Exp Med Articles Pregnancy results in an elevation in serum and tissue concentrations of the mononuclear phagocytic growth factor, CSF-1 (colony-stimulating factor 1). These increases are associated with an increase in the number of monocytes in the circulation, and with increases in the number of splenic macrophage precursors. In contrast to the approximately 2-fold elevation of the CSF-1 concentrations in serum and most tissues, pregnancy results in a 1,000-fold increase in the concentration of uterine CSF-1. The roughly fivefold elevation in uterine CSF-1 concentration observed at day 5 of pregnancy could be mimicked by administration of chorionic gonadotrophin in intact but not ovariectomized mice. These dramatic changes in uterine CSF-1 concentrations may indicate a role for CSF-1 in the regulation of nonmononuclear phagocytic cell types. The Rockefeller University Press 1986-09-01 /pmc/articles/PMC2188388/ /pubmed/3489064 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Regulation of colony-stimulating factor 1 during pregnancy |
title | Regulation of colony-stimulating factor 1 during pregnancy |
title_full | Regulation of colony-stimulating factor 1 during pregnancy |
title_fullStr | Regulation of colony-stimulating factor 1 during pregnancy |
title_full_unstemmed | Regulation of colony-stimulating factor 1 during pregnancy |
title_short | Regulation of colony-stimulating factor 1 during pregnancy |
title_sort | regulation of colony-stimulating factor 1 during pregnancy |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188388/ https://www.ncbi.nlm.nih.gov/pubmed/3489064 |