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Expression of the p53 oncogene in acute myeloblastic leukemia
We have investigated whether the p53 oncogene is expressed in the blast cells of patients with acute myeloblastic leukemia. p53 protein was detected in the blast cells of 19 out of 34 patients, but not in normal myelopoietic cells. We find a highly significant correlation between p53 protein synthes...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1986
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188393/ https://www.ncbi.nlm.nih.gov/pubmed/2427633 |
| _version_ | 1782146397837983744 |
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| collection | PubMed |
| description | We have investigated whether the p53 oncogene is expressed in the blast cells of patients with acute myeloblastic leukemia. p53 protein was detected in the blast cells of 19 out of 34 patients, but not in normal myelopoietic cells. We find a highly significant correlation between p53 protein synthesis in leukemic blast cells and the secondary plating efficiency of these cells (p = 0.0001). The latter provides an estimate for the self renewal capacity of progenitor cells in the blast population. These data indicate that p53 may be involved in leukemic stem cell renewal. |
| format | Text |
| id | pubmed-2188393 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1986 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-21883932008-04-17 Expression of the p53 oncogene in acute myeloblastic leukemia J Exp Med Articles We have investigated whether the p53 oncogene is expressed in the blast cells of patients with acute myeloblastic leukemia. p53 protein was detected in the blast cells of 19 out of 34 patients, but not in normal myelopoietic cells. We find a highly significant correlation between p53 protein synthesis in leukemic blast cells and the secondary plating efficiency of these cells (p = 0.0001). The latter provides an estimate for the self renewal capacity of progenitor cells in the blast population. These data indicate that p53 may be involved in leukemic stem cell renewal. The Rockefeller University Press 1986-09-01 /pmc/articles/PMC2188393/ /pubmed/2427633 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Articles Expression of the p53 oncogene in acute myeloblastic leukemia |
| title | Expression of the p53 oncogene in acute myeloblastic leukemia |
| title_full | Expression of the p53 oncogene in acute myeloblastic leukemia |
| title_fullStr | Expression of the p53 oncogene in acute myeloblastic leukemia |
| title_full_unstemmed | Expression of the p53 oncogene in acute myeloblastic leukemia |
| title_short | Expression of the p53 oncogene in acute myeloblastic leukemia |
| title_sort | expression of the p53 oncogene in acute myeloblastic leukemia |
| topic | Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188393/ https://www.ncbi.nlm.nih.gov/pubmed/2427633 |