Cytotoxic T lymphocytes against disease-associated determinant(s) in ankylosing spondylitis

Cytotoxic T lymphocytes, induced by stimulating the PBMC of an HLA-B27+ normal individual (B27+, AS-) with the PBMC of an HLA-identical sibling suffering from ankylosing spondylitis (AS) (B27+, AS+), specifically lyse B27+, AS+ PBMC but not PBMC from HLA-27+ or B27-, AS- normal controls, or from HLA...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188396/
https://www.ncbi.nlm.nih.gov/pubmed/3528379
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collection PubMed
description Cytotoxic T lymphocytes, induced by stimulating the PBMC of an HLA-B27+ normal individual (B27+, AS-) with the PBMC of an HLA-identical sibling suffering from ankylosing spondylitis (AS) (B27+, AS+), specifically lyse B27+, AS+ PBMC but not PBMC from HLA-27+ or B27-, AS- normal controls, or from HLA-B27- AS patients (B27-,AS+). CTL of similar specificity can also be raised by immunizing in vitro B27+,AS- cells with autologous cells modified by cross-reactive bacterial antigens. These results suggest that CTL can recognize certain bacterial antigens in association with HLA-B27 and that this interaction may lead to an inflammatory episode during the initial stages of the disease.
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spelling pubmed-21883962008-04-17 Cytotoxic T lymphocytes against disease-associated determinant(s) in ankylosing spondylitis J Exp Med Articles Cytotoxic T lymphocytes, induced by stimulating the PBMC of an HLA-B27+ normal individual (B27+, AS-) with the PBMC of an HLA-identical sibling suffering from ankylosing spondylitis (AS) (B27+, AS+), specifically lyse B27+, AS+ PBMC but not PBMC from HLA-27+ or B27-, AS- normal controls, or from HLA-B27- AS patients (B27-,AS+). CTL of similar specificity can also be raised by immunizing in vitro B27+,AS- cells with autologous cells modified by cross-reactive bacterial antigens. These results suggest that CTL can recognize certain bacterial antigens in association with HLA-B27 and that this interaction may lead to an inflammatory episode during the initial stages of the disease. The Rockefeller University Press 1986-09-01 /pmc/articles/PMC2188396/ /pubmed/3528379 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Cytotoxic T lymphocytes against disease-associated determinant(s) in ankylosing spondylitis
title Cytotoxic T lymphocytes against disease-associated determinant(s) in ankylosing spondylitis
title_full Cytotoxic T lymphocytes against disease-associated determinant(s) in ankylosing spondylitis
title_fullStr Cytotoxic T lymphocytes against disease-associated determinant(s) in ankylosing spondylitis
title_full_unstemmed Cytotoxic T lymphocytes against disease-associated determinant(s) in ankylosing spondylitis
title_short Cytotoxic T lymphocytes against disease-associated determinant(s) in ankylosing spondylitis
title_sort cytotoxic t lymphocytes against disease-associated determinant(s) in ankylosing spondylitis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188396/
https://www.ncbi.nlm.nih.gov/pubmed/3528379

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