Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation

We used a cloned, TNP-specific, MHC-restricted, human Th cell line, E- 11, and an assay of cognate Th-B cell interaction, BLAST-2 antigen expression on the B cell surface, to investigate the functional nature of the Th cell antigen receptor. We observed that E-11 induces BLAST-2 expression by restin...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188441/
https://www.ncbi.nlm.nih.gov/pubmed/2945894
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collection PubMed
description We used a cloned, TNP-specific, MHC-restricted, human Th cell line, E- 11, and an assay of cognate Th-B cell interaction, BLAST-2 antigen expression on the B cell surface, to investigate the functional nature of the Th cell antigen receptor. We observed that E-11 induces BLAST-2 expression by resting B cells in a hapten-dependent, hapten-specific, but MHC nonrestricted manner. The implication of these results for the Th cell receptor are discussed.
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spelling pubmed-21884412008-04-17 Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation J Exp Med Articles We used a cloned, TNP-specific, MHC-restricted, human Th cell line, E- 11, and an assay of cognate Th-B cell interaction, BLAST-2 antigen expression on the B cell surface, to investigate the functional nature of the Th cell antigen receptor. We observed that E-11 induces BLAST-2 expression by resting B cells in a hapten-dependent, hapten-specific, but MHC nonrestricted manner. The implication of these results for the Th cell receptor are discussed. The Rockefeller University Press 1986-11-01 /pmc/articles/PMC2188441/ /pubmed/2945894 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation
title Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation
title_full Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation
title_fullStr Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation
title_full_unstemmed Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation
title_short Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation
title_sort antigen-specific, mhc nonrestricted t helper cell-induced b cell activation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188441/
https://www.ncbi.nlm.nih.gov/pubmed/2945894

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