HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes

Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the virus nucleoprotein on infected cells. CTL preparations from four HLA B37-positive donors were shown to recognize a synthetic peptide that corresponded to amino acids 335-349 of the nucleoprotein sequence...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188455/
https://www.ncbi.nlm.nih.gov/pubmed/2430041
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collection PubMed
description Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the virus nucleoprotein on infected cells. CTL preparations from four HLA B37-positive donors were shown to recognize a synthetic peptide that corresponded to amino acids 335-349 of the nucleoprotein sequence. Influenza-specific CTL from 10 donors of other HLA types failed to recognize this epitope. CD8+ CTL lines were derived from lymphocytes of two HLA B37-positive donors and used to show that the peptide was represented on virus-infected cells and to determine the probable boundaries of the epitope.
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spelling pubmed-21884552008-04-17 HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes J Exp Med Articles Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the virus nucleoprotein on infected cells. CTL preparations from four HLA B37-positive donors were shown to recognize a synthetic peptide that corresponded to amino acids 335-349 of the nucleoprotein sequence. Influenza-specific CTL from 10 donors of other HLA types failed to recognize this epitope. CD8+ CTL lines were derived from lymphocytes of two HLA B37-positive donors and used to show that the peptide was represented on virus-infected cells and to determine the probable boundaries of the epitope. The Rockefeller University Press 1986-11-01 /pmc/articles/PMC2188455/ /pubmed/2430041 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes
title HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes
title_full HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes
title_fullStr HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes
title_full_unstemmed HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes
title_short HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes
title_sort hla b37 determines an influenza a virus nucleoprotein epitope recognized by cytotoxic t lymphocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188455/
https://www.ncbi.nlm.nih.gov/pubmed/2430041

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