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Thromboxane generation by human monocytes enhances platelet function
Human monocytes potentiate the ADP-stimulated aggregation of autologous platelets through a fourfold increased binding of 125I-fibrinogen to the platelet surface. The enhancement of platelet function is rapid, relatively transient and is due to thromboxane (Tx) synthesized by monocytes under these c...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1986
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188465/ https://www.ncbi.nlm.nih.gov/pubmed/3772299 |
| _version_ | 1782146414711668736 |
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| collection | PubMed |
| description | Human monocytes potentiate the ADP-stimulated aggregation of autologous platelets through a fourfold increased binding of 125I-fibrinogen to the platelet surface. The enhancement of platelet function is rapid, relatively transient and is due to thromboxane (Tx) synthesized by monocytes under these conditions. Tx generation by monocytes is triggered by the interaction between fibrinogen and the specific monocyte membrane receptor. These data suggest that the monocyte enhancement of platelet function combined with the clot-promoting activity of these cells might unbalance normal hemostasis. |
| format | Text |
| id | pubmed-2188465 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1986 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-21884652008-04-17 Thromboxane generation by human monocytes enhances platelet function J Exp Med Articles Human monocytes potentiate the ADP-stimulated aggregation of autologous platelets through a fourfold increased binding of 125I-fibrinogen to the platelet surface. The enhancement of platelet function is rapid, relatively transient and is due to thromboxane (Tx) synthesized by monocytes under these conditions. Tx generation by monocytes is triggered by the interaction between fibrinogen and the specific monocyte membrane receptor. These data suggest that the monocyte enhancement of platelet function combined with the clot-promoting activity of these cells might unbalance normal hemostasis. The Rockefeller University Press 1986-11-01 /pmc/articles/PMC2188465/ /pubmed/3772299 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Articles Thromboxane generation by human monocytes enhances platelet function |
| title | Thromboxane generation by human monocytes enhances platelet function |
| title_full | Thromboxane generation by human monocytes enhances platelet function |
| title_fullStr | Thromboxane generation by human monocytes enhances platelet function |
| title_full_unstemmed | Thromboxane generation by human monocytes enhances platelet function |
| title_short | Thromboxane generation by human monocytes enhances platelet function |
| title_sort | thromboxane generation by human monocytes enhances platelet function |
| topic | Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188465/ https://www.ncbi.nlm.nih.gov/pubmed/3772299 |