Paucity of phosphorylcholine-specific clones in B cells expressing the VHT15 gene product

The aim of this work was to study the cellular basis of the phenomenon of clonal dominance. To this end we analyzed two collections of BALB/c and C.B20 hybridomas that we selected on the basis of the expression of the VHT15 gene product independently from their antigen specificity. Our study demonst...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188473/
https://www.ncbi.nlm.nih.gov/pubmed/3491177
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description The aim of this work was to study the cellular basis of the phenomenon of clonal dominance. To this end we analyzed two collections of BALB/c and C.B20 hybridomas that we selected on the basis of the expression of the VHT15 gene product independently from their antigen specificity. Our study demonstrates that none of the 28 BALB/c and only 2 of the 29 C.B20 hybridomas obtained have variable regions that bind PC. We conclude therefore that the domination of the immune response to PC by particular variable regions cannot be due to the establishment of clonal dominance prior to immunization.
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spelling pubmed-21884732008-04-17 Paucity of phosphorylcholine-specific clones in B cells expressing the VHT15 gene product J Exp Med Articles The aim of this work was to study the cellular basis of the phenomenon of clonal dominance. To this end we analyzed two collections of BALB/c and C.B20 hybridomas that we selected on the basis of the expression of the VHT15 gene product independently from their antigen specificity. Our study demonstrates that none of the 28 BALB/c and only 2 of the 29 C.B20 hybridomas obtained have variable regions that bind PC. We conclude therefore that the domination of the immune response to PC by particular variable regions cannot be due to the establishment of clonal dominance prior to immunization. The Rockefeller University Press 1986-12-01 /pmc/articles/PMC2188473/ /pubmed/3491177 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Paucity of phosphorylcholine-specific clones in B cells expressing the VHT15 gene product
title Paucity of phosphorylcholine-specific clones in B cells expressing the VHT15 gene product
title_full Paucity of phosphorylcholine-specific clones in B cells expressing the VHT15 gene product
title_fullStr Paucity of phosphorylcholine-specific clones in B cells expressing the VHT15 gene product
title_full_unstemmed Paucity of phosphorylcholine-specific clones in B cells expressing the VHT15 gene product
title_short Paucity of phosphorylcholine-specific clones in B cells expressing the VHT15 gene product
title_sort paucity of phosphorylcholine-specific clones in b cells expressing the vht15 gene product
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188473/
https://www.ncbi.nlm.nih.gov/pubmed/3491177

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