A conserved human germline V kappa gene directly encodes rheumatoid factor light chains

The full-length gene that encodes the light chain variable regions of an idiotypically related group of human IgM kappa rheumatoid factors (RFs) has been cloned and sequenced. The deduced amino acid sequence is identical to four separate RF proteins. These results prove that genes capable of encodin...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188481/
https://www.ncbi.nlm.nih.gov/pubmed/3023521
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collection PubMed
description The full-length gene that encodes the light chain variable regions of an idiotypically related group of human IgM kappa rheumatoid factors (RFs) has been cloned and sequenced. The deduced amino acid sequence is identical to four separate RF proteins. These results prove that genes capable of encoding human anti-IgG autoantibody light chains without any somatic mutation are present in the kappa gene repertoire of normal people.
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spelling pubmed-21884812008-04-17 A conserved human germline V kappa gene directly encodes rheumatoid factor light chains J Exp Med Articles The full-length gene that encodes the light chain variable regions of an idiotypically related group of human IgM kappa rheumatoid factors (RFs) has been cloned and sequenced. The deduced amino acid sequence is identical to four separate RF proteins. These results prove that genes capable of encoding human anti-IgG autoantibody light chains without any somatic mutation are present in the kappa gene repertoire of normal people. The Rockefeller University Press 1986-12-01 /pmc/articles/PMC2188481/ /pubmed/3023521 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains
title A conserved human germline V kappa gene directly encodes rheumatoid factor light chains
title_full A conserved human germline V kappa gene directly encodes rheumatoid factor light chains
title_fullStr A conserved human germline V kappa gene directly encodes rheumatoid factor light chains
title_full_unstemmed A conserved human germline V kappa gene directly encodes rheumatoid factor light chains
title_short A conserved human germline V kappa gene directly encodes rheumatoid factor light chains
title_sort conserved human germline v kappa gene directly encodes rheumatoid factor light chains
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188481/
https://www.ncbi.nlm.nih.gov/pubmed/3023521

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