Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions

The possibility that the distribution of skin lesions in some cutaneous diseases is due to variations in the antigenic properties of skin was investigated by mapping the expression of the skin-specific pemphigus vulgaris and bullous pemphigoid antigens in different regions of the body. The expressio...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1986
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188484/
https://www.ncbi.nlm.nih.gov/pubmed/3537196
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collection PubMed
description The possibility that the distribution of skin lesions in some cutaneous diseases is due to variations in the antigenic properties of skin was investigated by mapping the expression of the skin-specific pemphigus vulgaris and bullous pemphigoid antigens in different regions of the body. The expression of both antigens was relatively stable within the same region, but varied between regions in a pattern that was distinct for each antigen. For each antigen there was a correlation between regions of high expression and location of skin lesions in autoimmune diseases involving the antigen. The results indicate that there are marked regional differences in the antigenic properties of skin and suggest this may influence the distribution of cutaneous lesions in some skin diseases.
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spelling pubmed-21884842008-04-17 Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions J Exp Med Articles The possibility that the distribution of skin lesions in some cutaneous diseases is due to variations in the antigenic properties of skin was investigated by mapping the expression of the skin-specific pemphigus vulgaris and bullous pemphigoid antigens in different regions of the body. The expression of both antigens was relatively stable within the same region, but varied between regions in a pattern that was distinct for each antigen. For each antigen there was a correlation between regions of high expression and location of skin lesions in autoimmune diseases involving the antigen. The results indicate that there are marked regional differences in the antigenic properties of skin and suggest this may influence the distribution of cutaneous lesions in some skin diseases. The Rockefeller University Press 1986-12-01 /pmc/articles/PMC2188484/ /pubmed/3537196 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions
title Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions
title_full Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions
title_fullStr Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions
title_full_unstemmed Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions
title_short Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions
title_sort regional variations in antigenic properties of skin. a possible cause for disease-specific distribution of skin lesions
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188484/
https://www.ncbi.nlm.nih.gov/pubmed/3537196

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