Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA

Mtf, a cytoplasmic, probably mitochondrial factor, controls Mta polymorphism. We tested for dominance between two forms of Mtf to determine whether Mta is controlled by positive or negative genetic mechanisms. We fused Mtf-disparate cells containing distinct mtDNA markers and selected for hybrids co...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188504/
https://www.ncbi.nlm.nih.gov/pubmed/3546577
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collection PubMed
description Mtf, a cytoplasmic, probably mitochondrial factor, controls Mta polymorphism. We tested for dominance between two forms of Mtf to determine whether Mta is controlled by positive or negative genetic mechanisms. We fused Mtf-disparate cells containing distinct mtDNA markers and selected for hybrids containing both. Such mtDNA heteroplasmons codominantly and stably express alternative Mta antigens. Stable codominance excludes negative genetic mechanisms as well as a model of induced nuclear compensation, and implies Mtf controls Mta expression through a positive genetic mechanism.
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spelling pubmed-21885042008-04-17 Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA J Exp Med Articles Mtf, a cytoplasmic, probably mitochondrial factor, controls Mta polymorphism. We tested for dominance between two forms of Mtf to determine whether Mta is controlled by positive or negative genetic mechanisms. We fused Mtf-disparate cells containing distinct mtDNA markers and selected for hybrids containing both. Such mtDNA heteroplasmons codominantly and stably express alternative Mta antigens. Stable codominance excludes negative genetic mechanisms as well as a model of induced nuclear compensation, and implies Mtf controls Mta expression through a positive genetic mechanism. The Rockefeller University Press 1987-02-01 /pmc/articles/PMC2188504/ /pubmed/3546577 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA
title Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA
title_full Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA
title_fullStr Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA
title_full_unstemmed Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA
title_short Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA
title_sort maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial dna
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188504/
https://www.ncbi.nlm.nih.gov/pubmed/3546577

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