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Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes

Human cytotoxic T cells specific for influenza A virus were tested for recognition of each of the ten influenza A virus proteins expressed in target cells using recombinant vaccinia viruses. They recognized the matrix M1, polymerase PB2, and nucleoproteins of influenza virus in association with MHC...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188513/
https://www.ncbi.nlm.nih.gov/pubmed/3029268
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description Human cytotoxic T cells specific for influenza A virus were tested for recognition of each of the ten influenza A virus proteins expressed in target cells using recombinant vaccinia viruses. They recognized the matrix M1, polymerase PB2, and nucleoproteins of influenza virus in association with MHC class I antigens. These internal viral proteins were seen by CTL in conjunction with one or more of the available dependent HLA gene products. There was no detectable recognition of influenza virus surface glycoproteins in target cells.
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spelling pubmed-21885132008-04-17 Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes J Exp Med Articles Human cytotoxic T cells specific for influenza A virus were tested for recognition of each of the ten influenza A virus proteins expressed in target cells using recombinant vaccinia viruses. They recognized the matrix M1, polymerase PB2, and nucleoproteins of influenza virus in association with MHC class I antigens. These internal viral proteins were seen by CTL in conjunction with one or more of the available dependent HLA gene products. There was no detectable recognition of influenza virus surface glycoproteins in target cells. The Rockefeller University Press 1987-02-01 /pmc/articles/PMC2188513/ /pubmed/3029268 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes
title Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes
title_full Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes
title_fullStr Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes
title_full_unstemmed Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes
title_short Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes
title_sort identification of viral molecules recognized by influenza-specific human cytotoxic t lymphocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188513/
https://www.ncbi.nlm.nih.gov/pubmed/3029268